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  2. Local blood flow regulation - Wikipedia

    en.wikipedia.org/wiki/Local_blood_flow_regulation

    Pulmonary (lung) circulation undergoes hypoxic vasoconstriction, which is a unique mechanism of local regulation in that the blood vessels in this organ react to hypoxemia, or low levels of dissolved oxygen in blood, in the opposite way as the rest of the body. While tissues and organs tend to increase blood flow by vasodilating in response to ...

  3. Alcohol-related brain damage - Wikipedia

    en.wikipedia.org/wiki/Alcohol-related_brain_damage

    Alcohol-related brain damage [1] [2] alters both the structure and function of the brain as a result of the direct neurotoxic effects of alcohol intoxication or acute alcohol withdrawal. Increased alcohol intake is associated with damage to brain regions including the frontal lobe , [ 3 ] limbic system , and cerebellum , [ 4 ] with widespread ...

  4. Opioid use disorder - Wikipedia

    en.wikipedia.org/wiki/Opioid_use_disorder

    The differences in the genetic regions encoding the dopamine receptors for each individual may help to elucidate part of the risk for opioid addiction and general substance abuse. [10] Studies of the D2 Dopamine Receptor, in particular, have shown some promising results. One specific SNP is at the TaqI RFLP (rs1800497).

  5. Effects of nicotine on human brain development - Wikipedia

    en.wikipedia.org/wiki/Effects_of_nicotine_on...

    Epinephrine stimulates the central nervous system and increases blood pressure, breathing, and heart rate. [ 30 ] As with most addictive substances, nicotine increases levels of a chemical messenger in the brain called dopamine, which affects parts of the brain that control reward (pleasure from natural behaviors such as eating). [ 30 ]

  6. Alcoholic cardiomyopathy - Wikipedia

    en.wikipedia.org/wiki/Alcoholic_cardiomyopathy

    These toxic substances can cause oxidative stress, inflammation, and damage to the cardiomyocytes, leading to the development of ACM. [ 3 ] Additionally, chronic alcohol consumption can lead to deficiencies in essential vitamins and minerals, such as thiamine, magnesium, and selenium, which are important for the proper functioning of the heart ...

  7. Physical dependence - Wikipedia

    en.wikipedia.org/wiki/Physical_dependence

    addictive drug – psychoactive substances that with repeated use are associated with significantly higher rates of substance use disorders, due in large part to the drug's effect on brain reward systems; dependence – an adaptive state associated with a withdrawal syndrome upon cessation of repeated exposure to a stimulus (e.g., drug intake)

  8. Cocaine intoxication - Wikipedia

    en.wikipedia.org/wiki/Cocaine_intoxication

    Cocaine increases alertness, feelings of well-being, euphoria, energy, sociability, and sexuality. The former are some of the desired effects of cocaine intoxication. Not having the normal use of mental faculties by reason of the introduction of cocaine is defined drug intoxication by the laws in America, Europe, and most of the rest of the World, and it is a serious crime in specific contexts ...

  9. Vasoconstriction - Wikipedia

    en.wikipedia.org/wiki/Vasoconstriction

    For example, vasoconstriction is a hypothermic preventative in which the blood vessels constrict and blood must move at a higher pressure to actively prevent a hypoxic reaction. ATP is used as a form of energy to increase this pressure to heat the body. Once homeostasis is restored, the blood pressure and ATP production regulates.