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The causes of macular edema are numerous and different causes may be inter-related. It is commonly associated with diabetes.Chronic or uncontrolled diabetes type 2 can affect peripheral blood vessels including those of the retina which may leak fluid, blood and occasionally fats into the retina causing it to swell.
Chances of disease progression are heavily influenced by blood sugar control, but on average 7% of those with diabetes experiencing proliferative diabetic retinopathy and 7% diabetic macular edema. [58] Diabetic retinopathy is the leading cause of vision loss in those 20–74 years old. [58]
Diabetes, for example, is the leading cause of new cases of blindness in those aged 20–74, with ocular manifestations such as diabetic retinopathy and macular edema affecting up to 80% of those who have had the disease for 15 years or more.
Diabetic Macular Edema (DME): is an eye disease specifically related to diabetes, occurring due to fluid build-up in the retina as a result of sustained high blood glucose levels. It can result in blurred vision and vision loss. [5] Eye floaters and spots: where visible cloud-like images appear to "float" in an individual's field of vision. [6]
In addition, imaging with a dynamic B-scan ultrasound may be useful for visualizing the retina. Causes and risk factors of VTS include age, a high degree of myopia or nearsightedness, macular degeneration, diabetic retinopathy, macular edema, and occlusion of the retinal vein. [3]
Recently, central serous chorioretinopathy has been understood to be part of the pachychoroid spectrum. [5] [6] In pachychoroid spectrum disorders, of which CSR represents stage II, the choroid, the highly vascularized layer below the retina, is thickened and congested with increased blood vessel diameter, especially in the deep choroid (the so-called Haller's layer).
In our pipeline, we're making great progress already this year advancing both BCX17725 in Netherton syndrome and avoralstat in diabetic macular edema toward meaningful clinical data readouts and ...
Diabetic papillopathy is a self-limiting disease that may affect both type 1 and type 2 diabetic patients. Unilateral or bilateral optic disc edema may occur. The exact etiology, pathogenesis and mechanism of the disc edema is unknown.
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