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Conjugated estrogens (CEs), or conjugated equine estrogens (CEEs), sold under the brand name Premarin among others, is an estrogen medication which is used in menopausal hormone therapy and for various other indications.
Equine estrogens, or horse estrogens ... Binding affinities were determined via displacement studies in a variety of in-vitro systems with labeled estradiol and ...
IM Tooltip Intramuscular or SC injection: Estradiol valerate – – 4 mg 1x/4 weeks Estradiol cypionate: 1 mg 1x/3–4 weeks: 3 mg 1x/3–4 weeks: 5 mg 1x/3–4 weeks Estradiol benzoate: 0.5 mg 1x/week: 1 mg 1x/week: 1.5 mg 1x/week SC implant: Estradiol: 25 mg 1x/6 months: 50 mg 1x/6 months: 100 mg 1x/6 months
Synthetic estradiol, taken orally, decomposes when absorbed in the gastrointestinal tract and delivers bioidentical estradiol to the bloodstream. [23] The hormone estriol, produced during pregnancy, is frequently compounded into bioidentical preparations in the United States.
Tritiated estradiol radioactivity in blood with a single intramuscular injection of 1.5 to 2.8 μg tritiated estradiol in aqueous solution in four women. [1] Peak blood radioactivity occurred within 15 minutes in three of the women and in the remaining woman after 2 hours. [1] Source: Davis et al. (1963). [1]
Estradiol has been used at high doses to suppress sex drive in men with sexual deviance such as paraphilias and in sex offenders. [84] [85] [86] It has specifically been used for this indication in the forms of intramuscular injections of estradiol valerate and estradiol undecylate and of subcutaneous pellet implants of estradiol. [84] [85] [86]
With intramuscular injections of estradiol valerate, it has been reported that a dose of 5 mg has a duration of 7 to 8 days, 10 mg a duration of 10 to 14 days, 40 mg a duration of 2 to 3 weeks (14 to 21 days), and 100 mg a duration of 3 to 4 weeks (21 to 28 days). [11] [12] [10]
Estradiol levels with combined injectable contraceptives [16] Preparation Form Dose Estradiol C max Estradiol T max; EV/NETE: Oil solution 5 mg/50 mg 232–428 pg/mL 2 days EC/MPA: Aqueous suspension 5 mg/25 mg 184–736 pg/mL 2–4 days EEn/DHPA: Oil solution 10 mg/150 mg 314–317 pg/mL 4.2–8.1 days 5 mg/75 mg 148 pg/mL 6.5 days
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