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  2. Aldosterone synthase - Wikipedia

    en.wikipedia.org/wiki/Aldosterone_synthase

    Aldosterone synthase, also called steroid 18-hydroxylase, corticosterone 18-monooxygenase or P450C18, is a steroid hydroxylase cytochrome P450 enzyme involved in the biosynthesis of the mineralocorticoid aldosterone and other steroids. The enzyme catalyzes sequential hydroxylations of the steroid angular methyl group at C18 after initial 11β ...

  3. Hypoaldosteronism - Wikipedia

    en.wikipedia.org/wiki/Hypoaldosteronism

    Hypoaldosteronism causes low sodium (hyponatremia), high potassium (hyperkalemia), and metabolic acidosis, a condition in which the body produces excess acid.These conditions are responsible for the symptoms of hypoaldosteronism, which include muscle weakness, nausea, palpitations, irregular heartbeat, and abnormal blood pressure.

  4. Primary aldosteronism - Wikipedia

    en.wikipedia.org/wiki/Primary_aldosteronism

    About 35% of the cases are caused by a single aldosterone-secreting adenoma, a condition known as Conn's syndrome. [ 7 ] [ 8 ] Many patients experience fatigue, potassium deficiency and high blood pressure which may cause poor vision, confusion or headaches .

  5. Glucocorticoid remediable aldosteronism - Wikipedia

    en.wikipedia.org/wiki/Glucocorticoid_remediable...

    The genes encoding aldosterone synthase and 11β-hydroxylase are 95% identical and are close together on chromosome 8. In individuals with GRA, there is unequal crossing over so that the 5' regulatory region of the 11-hydroxylase gene is fused to the coding region of the aldosterone synthase. [citation needed]

  6. Adrenal insufficiency - Wikipedia

    en.wikipedia.org/wiki/Adrenal_insufficiency

    In adrenal insufficiency, there is a deficiency in cortisol production which may be accompanied by a deficiency in aldosterone production (predominantly in primary adrenal insufficiency). [2] [3] Depending on the cause and type of adrenal insufficiency, the mechanism of the disease differs. Generally, the symptoms manifest through the systemic ...

  7. Steroidogenic enzyme - Wikipedia

    en.wikipedia.org/wiki/Steroidogenic_enzyme

    18-Hydroxylase (aldosterone synthase) – mineralocorticoid synthesis; 21-Hydroxylase – corticosteroid synthesis; Cytochrome P450 (CYP1, 2, 3) – estrogen metabolism; Hydroxysteroid dehydrogenases (and ketosteroid reductases) 3α-Hydroxysteroid dehydrogenase – androgen, progestogen, and neurosteroid synthesis and metabolism

  8. Congenital adrenal hyperplasia - Wikipedia

    en.wikipedia.org/wiki/Congenital_adrenal_hyperplasia

    Hyponatremia (due to hypoaldosteronism) - Aldosterone is the end product of the renin-angiotensin-aldosterone system that regulates blood pressure via blood pressure surveillance in the Kidney Juxtaglomerular apparatus. Aldosterone normally functions to increase sodium retention (which brings water as well) in exchange for potassium.

  9. Adrenal gland disorder - Wikipedia

    en.wikipedia.org/wiki/Adrenal_gland_disorder

    Hypoaldosteronism is a clinical condition marked by either an aldosterone deficiency or impaired tissue-level action of the hormone. Angiotensin I to Angiotensin II conversion, adrenal aldosterone synthesis and secretion, abnormal target tissue response to aldosterone, and renal renin production and secretion are all potential causes of the ...