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Solitary rectal ulcer syndrome (SRUS) is a rare benign disease characterized by symptoms, clinical findings, and histological abnormalities. [9] Only 40% of patients have ulcers; 20% of patients have a single ulcer, and the remaining lesions range in size and form from broad-based polypoid to hyperemic mucosa. [10]
The most common signs and symptoms are bleeding, which can vary from minor to severe, rectal prolapse and incomplete evacuation (35%-76% of cases). [4] According to one report, constipation is present in about 55% of cases, but diarrhea is present in 20%–40% of cases. [1] Reported symptoms are: Hematochezia (lower gastrointestinal bleeding).
Peptic ulcer disease is when the inner part of the stomach's gastric mucosa (lining of the stomach), the first part of the small intestine, or sometimes the lower esophagus, gets damaged. An ulcer in the stomach is called a gastric ulcer , while one in the first part of the intestines is a duodenal ulcer . [ 1 ]
Chronic constipation; Fecal incontinence – paradoxical overflow diarrhea as a result of liquid stool passing around the obstruction; Abdominal pain and bloating; Loss of appetite; Complications may include necrosis and ulcers of the rectal tissue, which if untreated can cause death. [citation needed]
That can cause more frequent bowel movements and loose stool or diarrhea, says Dr. Karen Tang, a gynecologist and the author of It’s Not Hysteria, a book about reproductive health.
Oral symptoms can be similar to lesions occurring elsewhere in the digestive tract, with a pattern of swelling, inflammation, ulcers, and fissures. If these signs are present, then patients are more likely to also have anal and esophageal lesions and experience other extra-intestinal disease manifestations. [2]
Other diseases may cause an increased excretion of fecal calprotectin, such as infectious diarrhea, untreated celiac disease, necrotizing enterocolitis, intestinal cystic fibrosis and neoplastic pediatric tumor cells. [68] Liver function tests are often elevated in IBD, and are often mild and generally return spontaneously to normal levels. [69]
This fulminant type is associated with severe symptoms (usually diarrhea, rectal bleeding and abdominal pain) and is usually associated with systemic symptoms including fever. [13] It is associated with a high mortality rate as compared to milder forms of UC, with a 3-month and 12 month mortality rate of 0.84% and 1% respectively. [ 13 ]