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A Cochrane review, though, found that metformin was only slightly effective for decreasing androgen levels in women with PCOS. [119] Metformin also has significant effects on the gut microbiome, such as its effect on increasing agmatine production by gut bacteria, but the relative importance of this mechanism compared to other mechanisms is ...
Polycystic ovary syndrome, or polycystic ovarian syndrome (PCOS), is the most common endocrine disorder in women of reproductive age. [14] The syndrome is named after cysts which form on the ovaries of some women with this condition, though this is not a universal symptom, and not the underlying cause of the disorder.
Side effects of metformin are typically mild and include GI (gastrointestinal) issues like gas, diarrhea or bloating. However, the FDA warns against using metformin if you have kidney disease or a ...
It therefore concluded that the benefit of metformin in the improvement of reproductive outcomes in women with PCOS is limited. [17] The ESHRE/ASRM-sponsored Consensus workshop does not recommend metformin for ovulation stimulation. [18] Subsequent randomized studies have confirmed the lack of evidence for adding metformin to clomiphene. [19]
Metformin is a tool to support lifestyle changes for conditions including type 2 diabetes and PCOS and is best used in conjunction with regular exercise, following a balanced diet, good sleep ...
Metformin can help to decrease weight and androgen levels. [72] When combined with lifestyle modifications (changes in diet and exercise), it has been linked with lower body mass index and a reduction in menstrual problems. [72] However, the use of metformin in women with PCOS should only be considered in patients with impaired glucose ...
Diarrhea is a well-known side effect of metformin. Learn more about why this gut-related side effect happens and how to manage it.
In women with insulin resistance, such as those with polycystic ovary syndrome, androgen levels are often elevated. [184] Metformin, an insulin-sensitizing medication, has indirect antiandrogenic effects in such women, decreasing testosterone levels by as much as 50% secondary to its beneficial effects on insulin sensitivity. [184] [185] [186]
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