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Enclomifene (INN Tooltip International Nonproprietary Name), or enclomiphene (USAN Tooltip United States Adopted Name), a nonsteroidal selective estrogen receptor modulator of the triphenylethylene group, acts by antagonizing the estrogen receptor (ER) in the pituitary gland, which reduces negative feedback by estrogen on the hypothalamic-pituitary-gonadal axis, thereby increasing gonadotropin ...
Clomifene has an onset of action of 5 to 10 days following course of treatment and an elimination half-life about 4 - 7days. [2] [4] In one study, after a single 50 mg dose of clomifene, the half-life of clomifene was 128 hours (5.3 days), of 4-hydroxyclomifene was 13 hours, and of 4-hydroxy-N-desmethylclomifene was 15 hours. [2]
Hypogonadism means diminished functional activity of the gonads —the testicles or the ovaries —that may result in diminished production of sex hormones. Low androgen (e.g., testosterone) levels are referred to as hypoandrogenism and low estrogen (e.g., estradiol) as hypoestrogenism. These are responsible for the observed signs and symptoms ...
Condom-associated erection problem (CAEP) is erectile dysfunction experienced due to condoms. [1] CAEP can occur in young and healthy men who otherwise have no erectile dysfunctions, although men who experience CAEP have greater odds of having mild-to-moderate erectile dysfunction. CAEP has the effect of discouraging condom use by both males ...
Erectile dysfunction (ED), also referred to as impotence, is a form of sexual dysfunction in males characterized by the persistent or recurring inability to achieve or maintain a penile erection with sufficient rigidity and duration for satisfactory sexual activity. It is the most common sexual problem in males and can cause psychological ...
Venous leak, also called venogenic erectile dysfunction and penile venous insufficiency, is one category of vasculogenic impotence — a cause of erectile dysfunction in males. [2] It affects all ages, being particularly awkward in young men. [3] Much about venous leaks has not reached a consensus among the medical community, and many aspects ...
Selective estrogen receptor modulators (SERMs), also known as estrogen receptor agonists/antagonists (ERAAs), [1][2] are a class of drugs that act on estrogen receptors (ERs). [3] Compared to pure ER agonists – antagonists (e.g., full agonists and silent antagonists), SERMs are more tissue-specific, allowing them to selectively inhibit or ...
An adult penis that is abnormally small but otherwise normally formed is referred to in medicine as a micropenis, with the cutoff usually being defined as around 3 inches (7.6 cm). A large, uncircumcised human penis, flaccid and erect. Flaccid length is a poor predictor for erect length.
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