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In 2020, the sequencing of ancient dog genome indicates that in two Mexican breeds the Chihuahua and Xoloitzcuintli derive 4% and 3% of their ancestry from pre-colonial dogs, [10] almost entirely being descended from Eurasian dogs. Their phenotype is a consequence of canine ectodermal dysplasia caused by a mutation on the FOXI3 autosomal gene. [11]