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It is referred to as the mitotic spindle during mitosis, a process that produces genetically identical daughter cells, or the meiotic spindle during meiosis, a process that produces gametes with half the number of chromosomes of the parent cell. Besides chromosomes, the spindle apparatus is composed of hundreds of proteins.
Astral microtubules anchor the spindle poles to the cell membrane. Microtubule polymerization is nucleated at the microtubule organizing center . An aster is a cellular structure shaped like a star , consisting of a centrosome and its associated microtubules during the early stages of mitosis in an animal cell.
The spindle checkpoint, or SAC (for spindle assembly checkpoint), also known as the mitotic checkpoint, is a cellular mechanism responsible for detection of: correct assembly of the mitotic spindle; attachment of all chromosomes to the mitotic spindle in a bipolar manner; congression of all chromosomes at the metaphase plate.
An acentric chromosome is fragment of a chromosome that lacks a centromere. Since centromeres are the attachment point for spindle fibers in cell division, acentric fragments are not evenly distributed to daughter cells during cell division. As a result, a daughter cell will lack the acentric fragment and deleterious consequences could occur.
The microtubule-organizing center (MTOC) is a structure found in eukaryotic cells from which microtubules emerge. MTOCs have two main functions: the organization of eukaryotic flagella and cilia and the organization of the mitotic and meiotic spindle apparatus, which separate the chromosomes during cell division.
Centralspindlin is required for the assembly of the mitotic spindle [3] as well as for microtubule bundling and anchoring of midbody microtubules to the plasma membrane. [ 1 ] [ 2 ] This complex is also implicated in tethering the spindle apparatus to the plasma membrane during cytokinesis [ 4 ] This interaction permits cleavage furrow ingression.
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The spindle checkpoint, also known as the metaphase-to-anaphase transition, the spindle assembly checkpoint (SAC), the metaphase checkpoint, or the mitotic checkpoint, is a cell cycle checkpoint during metaphase of mitosis or meiosis that prevents the separation of the duplicated chromosomes until each chromosome is properly attached to the ...