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Carcinoid syndrome thus may produce niacin deficiency and clinical manifestations of pellagra. Anti-tuberculosis medication tends to bind to vitamin B 6 and reduce niacin synthesis, since B 6 (pyridoxine) is a required cofactor in the tryptophan-to-niacin reaction. Several therapeutic drugs can provoke pellagra.
A man with pellagra, which is caused by a chronic lack of vitamin B 3 in the diet. Severe deficiency of niacin in the diet causes the disease pellagra, characterized by diarrhea, sun-sensitive dermatitis involving hyperpigmentation and thickening of the skin (see image), inflammation of the mouth and tongue, delirium, dementia, and if left untreated, death. [7]
About 1 in 4 Americans have too much niacin in their body from eating meats and nuts, ... But even though niacin deficiency is a rarity in the U.S., some people do take it as a dietary supplement ...
Niacin has been linked to a higher risk of heart disease. It is often added to flour and fortified cereals in the U.S. The B vitamin used to be a popular medication to lower high cholesterol.
Niacin deficiency is a consequence of a diet low in both niacin and the amino acid tryptophan, a precursor for the vitamin. Low plasma tryptophan is a non-specific indicator, meaning it can have other causes. The signs and symptoms of niacin deficiency start to revert within days of oral supplementation with large amounts of the vitamin. [23] [24]
Likewise, if you have a vitamin deficiency, it’s probably best to keep your supply fresh. “People with malabsorption in their stomach or intestines, such as patients after weight loss surgery ...
Micronutrient deficiency is defined as the sustained insufficient supply of vitamins and minerals needed for growth and development, as well as to maintain optimal health. Since some of these compounds are considered essentials (we need to obtain them from the diet), micronutrient deficiencies are often the result of an inadequate intake.
Hartnup disease (also known as "pellagra-like dermatosis" [1] and "Hartnup disorder" [2]) is an autosomal recessive [3] metabolic disorder affecting the absorption of nonpolar amino acids (particularly tryptophan that can be, in turn, converted into serotonin, melatonin, and niacin).