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Homeobox genes encode homeodomain protein products that are transcription factors sharing a characteristic protein fold structure that binds DNA to regulate expression of target genes. [ 3 ] [ 4 ] [ 2 ] Homeodomain proteins regulate gene expression and cell differentiation during early embryonic development, thus mutations in homeobox genes can ...
The same Hox protein can act as a repressor at one gene and an activator at another. The ability of Hox proteins to bind DNA is conferred by a part of the protein referred to as the homeodomain. The homeodomain is a 60-amino-acid-long DNA-binding domain (encoded by its corresponding 180-base-pair DNA sequence, the homeobox
Men who inherit a rare (<0.1% in a selected group of patients without clinical signs of prostate cancer) genetic variant in HOXB13 (G84E or rs138213197) have a 10-20-fold increased risk of prostate cancer. [7] [8]
Homeobox protein Hox-C6 is a protein that in humans is encoded by the HOXC6 gene. [5] [6] [7] Hox-C6 expression is highest in the fallopian tube and ovary. [8]HoxC6 has been highly expressed in many types of cancers including prostate, breast, and esophageal squamous cell cancer.
Homeobox protein Hox-A9 is a protein that in humans is encoded by the HOXA9 gene. [5] [6]In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes.
Homeodomain proteins are transcription factors that share a DNA-binding domain called the homeodomain. [1] Changes in the expression and function of homeotic genes are responsible for the changes in the morphology of the limbs of arthropods as well as in the axial skeletons of vertebrates.
71950 Ensembl ENSG00000111704 ENSMUSG00000012396 UniProt Q9H9S0 Q80Z64 RefSeq (mRNA) NM_001297698 NM_024865 NM_028016 NM_001289828 NM_001289830 NM_001289831 RefSeq (protein) NP_001284627 NP_079141 NP_001276757 NP_001276759 NP_001276760 NP_082292 Location (UCSC) Chr 12: 7.79 – 7.8 Mb Chr 6: 122.68 – 122.69 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Homeobox protein NANOG ...
15394 Ensembl ENSG00000105991 ENSMUSG00000029844 UniProt P49639 P09022 RefSeq (mRNA) NM_153620 NM_005522 NM_010449 NM_001311118 RefSeq (protein) NP_005513 NP_705873 n/a Location (UCSC) Chr 7: 27.09 – 27.1 Mb Chr 6: 52.13 – 52.14 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Homeobox protein Hox-A1 is a protein that in humans is encoded by the HOXA1 gene. Gene Two transcript ...