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The biology of depression is the attempt to identify a biochemical origin of depression, as opposed to theories that emphasize psychological or situational causes. Scientific studies have found that different brain areas show altered activity in humans with major depressive disorder (MDD) . [ 1 ]
In most mammals, including humans, it only occurs in the subgranular zone of the hippocampus, and in the olfactory bulb. [1] The neurogenesis hypothesis of depression proposes that major depressive disorder is caused, at least partly, by impaired neurogenesis in the subgranular zone of the hippocampus. [2]
Depression, which may be a similar kind of defense mechanism, may have become dysregulated as well. [31] Thus, unlike other evolutionary theories this one sees depression as a maladaptive extreme of something that is beneficial in smaller amounts. In particular, one theory focuses on the personality trait neuroticism. Low amounts of neuroticism ...
The neurotrophic hypothesis of depression [1] proposes that major depressive disorder (MDD) is caused, at least partly, by impaired neurotrophic support.Neurotrophic factors (also known as neurotrophins) are a family of closely related proteins which regulate the survival, development, and function of neurons in both the central and peripheral nervous systems.
The Baldwin effect compared to Lamarck's theory of evolution, Darwinian evolution, and Waddington's genetic assimilation. All the theories offer explanations of how organisms respond to a changed environment with adaptive inherited change. In evolutionary biology, the Baldwin effect describes an effect of learned behaviour on evolution.
The framework suggests that a lack of self-acceptance lies at the root of depression and that one can heal their own depression if they (a) keep an alert eye to their own emotional state (i.e., identify feelings of shame or depression) and (b) upon identification, take reparative action: undergo a context shift and immerse oneself in a new ...
Researchers theorized that depression was caused by a chemical imbalance in neurotransmitters in the brain, a theory based on observations made in the 1950s of the effects of reserpine and isoniazid in altering monoamine neurotransmitter levels and affecting depressive symptoms. [90]
The kindling hypothesis of depression posits that each period of depression in someone with major depressive disorder (MDD) causes neurological changes that predispose the person to future episodes. While the first episode of depression is often triggered by major life events, future episodes are less likely to be tied to circumstantial factors ...