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Antihormone therapy is a type of hormone therapy that suppresses selected hormones or their effects, in contrast with hormone replacement therapy, which encourages hormone activity. The suppression of certain hormones can benefit patients with certain cancers because certain hormones prompt or help the growth of a tumor . [ 1 ]
Ovarian stimulation with the aromatase inhibitor letrozole has been proposed for ovulation induction in order to treat unexplained female infertility. In a multi-center study funded by the National Institute of Child Health and Development, ovarian stimulation with letrozole resulted in a significantly lower frequency of multiple gestation (i.e., twins or triplets) but also a lower frequency ...
A depressogen is a substance that causes or can cause depression, usually as a side effect. [1] They are the functional opposites of antidepressants. [2]Examples of drugs commonly associated with depressogenic effects include ethanol, some anticonvulsants such as the barbiturates (e.g. phenobarbital), benzodiazepines (e.g. diazepam), vigabatrin, and topiramate, corticosteroids like ...
[6] [8] If nonsteroidal aromatase Inhibitors are not working or patients are relapsing, then the use of steroidal aromatase inhibitors could be applied for better results before patients will be forced to switch from endocrine therapy to cytotoxic chemotherapy and therefore avoiding or delaying the side effects and complications of the latter. [6]
The first aromatase inhibitor that was discovered was aminoglutethimide, classified as first-generation AIs. It is still used today despite causing side effects such as lack of target enzyme specificity which also has effects on other cytochrome P450 enzymes. [12] Furthermore, it affects the synthesis of aldosterone, thyroid hormone and ...
Aromatase inhibitors are an important class of drugs used for the treatment of breast cancer in postmenopausal women. At menopause, estrogen production in the ovaries ceases, but other tissues continue to produce estrogen through the action of the enzyme aromatase on androgens produced by the adrenal glands.
[7] [6] Severe side effects include an increased risk of heart disease and osteoporosis. [7] Use during pregnancy may harm the baby. [7] Anastrozole is in the aromatase-inhibiting family of medications. [7] It works by blocking the production of estrogens in the body, and hence has antiestrogenic effects. [7]
Estrogen deprivation therapy, also known as endocrine therapy, is a form of hormone therapy that is used in the treatment of breast cancer.Modalities include antiestrogens or estrogen blockers such as selective estrogen receptor modulators (SERMs) like tamoxifen, selective estrogen receptor degraders like fulvestrant, and aromatase inhibitors like anastrozole and ovariectomy.
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