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  2. Benzonitrile - Wikipedia

    en.wikipedia.org/wiki/Benzonitrile

    Benzonitrile is the chemical compound with the formula C 6 H 5 (CN), abbreviated PhCN. This aromatic organic compound is a colorless liquid with a sweet bitter almond odour. It is mainly used as a precursor to the resin benzoguanamine .

  3. 4-Cyano-3-(trifluoromethyl)aniline - Wikipedia

    en.wikipedia.org/wiki/4-Cyano-3-(trifluoromethyl...

    4-Cyano-3-(trifluoromethyl)aniline, also known as 4-amino-2-(trifluoromethyl)benzonitrile, is a cyanated and trifluoromethylated derivative of aniline. It is the starting material in one of the chemical syntheses of the nonsteroidal antiandrogen bicalutamide .

  4. Ligandrol - Wikipedia

    en.wikipedia.org/wiki/Ligandrol

    LGD-4033 has been assessed in clinical trials at single doses ranging from 0.1 to 22 mg and at repeated doses ranging from 0.1 to 2 mg/day for 3 to 12 weeks. [11] The drug sold via black-market Internet suppliers and used non-medically is often taken at much higher doses than those used in repeated-dose clinical trials (e.g., 5–10 mg/day), with unknown adverse effects and risks.

  5. Trifluoromethyl group - Wikipedia

    en.wikipedia.org/wiki/Trifluoromethyl_group

    The trifluoromethyl group is a functional group that has the formula-CF 3. The naming of is group is derived from the methyl group (which has the formula -CH 3), by replacing each hydrogen atom by a fluorine atom. Some common examples are trifluoromethane H– CF 3, 1,1,1-trifluoroethane H 3 C – CF 3, and hexafluoroacetone F 3 C –CO– CF 3.

  6. Trifluorotoluene - Wikipedia

    en.wikipedia.org/wiki/Trifluorotoluene

    A derivative of trifluorotoluene, 3-aminobenzotrifluoride, is the precursor to the herbicide fluometuron. [3] It is synthesized via nitration followed by reduction to meta-H 2 NC 6 H 4 CF 3. This aniline is then converted to the urea. Flumetramide (6-[4-(trifluoromethyl)phenyl]morpholin-3-one), a skeletal muscle relaxant, is also prepared from ...

  7. Transition metal nitrile complexes - Wikipedia

    en.wikipedia.org/wiki/Transition_metal_nitrile...

    Typical nitrile ligands are acetonitrile, propionitrile, and benzonitrile.The structures of [Ru(NH 3) 5 (NCPh)] n+ have been determined for the 2+ and 3+ oxidation states. Upon oxidation the Ru-NH 3 distances contract and the Ru-NCPh distances elongate, consistent with amines serving as pure-sigma donor ligands and nitriles functioning as pi-acceptors.

  8. Letts nitrile synthesis - Wikipedia

    en.wikipedia.org/wiki/Letts_nitrile_synthesis

    [11] 4-(trifluoromethyl)benzonitrile, produced by the Nickel catalyzed cyanation of 4-chlorobenzotrifluoride is a precursor for the antidepressant Fluvoxamine. [12] Restrosynthesis of Fluvoxamine. Benzonitrile can also act a ligand in asymmetric catalysis, coordinating to transition metals and forming Lewis acids. [13] [14]

  9. Total base number - Wikipedia

    en.wikipedia.org/wiki/Total_Base_Number

    A colour-indicator titration, for example using test method ASTM D974, can be carried out to indicate relative changes that occur in an oil sample during its use under oxidising conditions. A sample is dissolved in a solvent mixture of Toluene/ Propan-2-ol with 0.5% deionised water.