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Benzo[a]pyrene (BaP or B[a]P) is a polycyclic aromatic hydrocarbon and the result of incomplete combustion of organic matter at temperatures between 300 °C (572 °F) and 600 °C (1,112 °F).
The mechanism of action of benzo[a]pyrene-related DNA modification has been investigated extensively and relates to the activity of cytochrome P450 subclass 1A1 . [3] Seemingly, the high activity of CYP1A1 in the intestinal mucosa prevents major amounts of ingested benzo[a]pyrene from entering portal blood and systemic circulation. [4]
This category reflects the organization of International Statistical Classification of Diseases and Related Health Problems, 10th Revision. Generally, diseases outlined within the ICD-10 codes T36-T50 within Chapter XIX: Injury, poisoning and certain other consequences of external causes should be included in this category.
Benzo[a]pyrene now has been well characterized in toxicology reports and is a known potent carcinogen. [10] Benzo[ a ]pyrene requires metabolic activation to become, ultimately, BPDE ((±)- anti -7β,8α-dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo[ a ]pyrene) which binds to the DNA to form a covalent trans adducts at the N2 position of ...
A DNA adduct (at center) of a metabolite of benzo[a]pyrene. (+)-Benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide has been shown to bind to an N2 atom of a guanine nucleobase in DNA, [2] [3] distorting the double helix structure [4] by intercalation of the pyrene moiety between base pairs through π-stacking. [5]
(like numbers place letters first are omitted while indexing compounds, later on they are added again if necessary) the proper name for this compound is Benzo[a]anthracene. Pyrene: Benzo[a]pyrene, by adding 4 carbon atoms to pyrene the left most ring is the extra one. Benzo[e]pyrene, by adding 4 carbon atoms to the pyrene along its short axis.
Benzo[e]pyrene; Perylene This page was last edited on 30 June 2019, at 23:36 (UTC). Text is available under the Creative Commons Attribution-ShareAlike 4.0 ...
Benzodiazepines are one of the most highly prescribed classes of drugs, [7] and they are commonly used in self-poisoning. [8] [9] Over 10 years in the United Kingdom, 1512 fatal poisonings have been attributed to benzodiazepines with or without alcohol. [10] Temazepam was shown to be more toxic than the majority of benzodiazepines.