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Dorzolamide/timolol, sold under the brand name Cosopt among others, is a medication used to treat high pressure inside the eye including glaucoma. [3] [5] [6] It is a combination of dorzolamide hydrochloride and timolol maleate. [3] It may be used when a beta blocker, like timolol, is not sufficient alone. [7] It is used as an eye drop. [3]
Side effects in less than 10% of people include other eye problems such as itching, foreign body sensation or dry eye, as headache or hyperpigmentation (darkening) of the skin around the eye. [ 4 ] Hyperpigmentation is an adverse effect of bimatoprost, [ 5 ] while the others are fairly common for eye drops in general.
Timolol can also lead to fainting, congestive heart failure, depression, confusion, worsening of Raynaud's syndrome and impotence. [23] Side effects when given in the eye include: burning sensation, eye redness, superficial punctate keratopathy, corneal numbness. [25] [14]
Travoprost/timolol, sold under the brand name Duotrav among others, is a fixed-dose combination medication used for the treatment of glaucoma. [4] [5] ...
Brimonidine/timolol, sold under the brand name Combigan among others, is a fixed-dose combination medication eye drop used for the treatment of glaucoma. [1] It is a combination of brimonidine (an α 2 adrenergic agonist) and timolol (a β adrenergic blocker).
While definitive sites of metabolism have not been firmly established, there are several metabolites worthy of note. N-Desethylbrinzolamide is an active metabolite of the parent compound, and thus exhibits carbonic anhydrase inhibitory activity (largely carbonic anhydrase-I, when in the presence of Brinzolamide) and also accumulates in the erythrocytes.
Common side effects when used on the skin include redness, burning, and headaches. [5] More significant side effects may include allergic reactions and low blood pressure. [5] [4] Use in pregnancy appears to be safe. [5] [4] When applied to the eye it works by decreasing the amount of aqueous humor made while increasing the amount that drains ...
The most common side effect is eye irritation felt as stinging or burning, which occurs in up to a third of patients. Blepharoconjunctivitis occurs in up to 5% of patients. Rarer adverse effects include keratitis, edema and increased lacrimation. [3] [4] Allergies are rare, but seem to be more common than under the related drug timolol. [2]