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  2. Huntington's disease - Wikipedia

    en.wikipedia.org/wiki/Huntington's_disease

    Huntington's disease (HD), also known as Huntington's chorea, is an incurable neurodegenerative disease [7] that is mostly inherited. [8] The earliest symptoms are often subtle problems with mood or mental/psychiatric abilities. [9] [1] A general lack of coordination and an unsteady gait often follow. [2]

  3. Nancy Wexler - Wikipedia

    en.wikipedia.org/wiki/Nancy_Wexler

    Nancy Wexler (born 19 July 1945) [1] FRCP MEASA is an American geneticist and the Higgins Professor of Neuropsychology in the Departments of Neurology and Psychiatry of the Columbia University College of Physicians and Surgeons, best known for her involvement in the discovery of the location of the gene that causes Huntington's disease.

  4. Neurodegenerative disease - Wikipedia

    en.wikipedia.org/wiki/Neurodegenerative_disease

    Neurodegenerative diseases include amyotrophic lateral sclerosis, multiple sclerosis, Parkinson's disease, Alzheimer's disease, Huntington's disease, multiple system atrophy, tauopathies, and prion diseases. Neurodegeneration can be found in the brain at many different levels of neuronal circuitry, ranging from molecular to systemic. [4]

  5. Clinical neurochemistry - Wikipedia

    en.wikipedia.org/wiki/Clinical_neurochemistry

    Progression of Huntington's Disease. A microscope image of Medium spiny neurons (yellow) with nuclear inclusions (orange), which occur as part of the disease process. Clinical neurochemistry is the field of neurological biochemistry which relates biochemical phenomena to clinical symptomatic manifestations in humans.

  6. Huntingtin - Wikipedia

    en.wikipedia.org/wiki/Huntingtin

    Huntingtin (Htt) is the protein coded for in humans by the HTT gene, also known as the IT15 ("interesting transcript 15") gene. [5] Mutated HTT is the cause of Huntington's disease (HD), and has been investigated for this role and also for its involvement in long-term memory storage.

  7. Subcortical dementia - Wikipedia

    en.wikipedia.org/wiki/Subcortical_dementia

    Subcortical dementias includes those diseases which predominantly affects the basal ganglia along with features of cognitive decline. Diseases such as progressive supranuclear palsy, Huntington's chorea and Parkinson's disease are different in many features from the other cortical dementias like Alzheimer's disease. Yet these patients present ...

  8. Lynette Tippett - Wikipedia

    en.wikipedia.org/wiki/Lynette_Tippett

    Tippett's research focuses on the psychosocial, emotional and cognitive effects of the brain changes that take place in neurodegenerative diseases, such as Huntington's disease, Alzheimer's, frontotemporal dementia and Parkinson's disease, and also due to traumatic brain injury. [2]

  9. Central nervous system disease - Wikipedia

    en.wikipedia.org/wiki/Central_nervous_system_disease

    Huntington's disease is a degenerative neurological disorder that is inherited. Degeneration of neuronal cells occurs throughout the brain, especially in the striatum. There is a progressive decline that results in abnormal movements. [31] Statistics show that Huntington's disease may affect 10 per 100,000 people of Western European descent.

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