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For instance, if the ADI is based on data from humans the safety factor is usually 10 instead of 100. The ADI is usually given in mg per kg body weight. [5] The ADI is considered a safe intake level for a healthy adult of normal weight who consumes an average daily amount of the substance in question.
Vancomycin is recommended to be administered in a dilute solution slowly, over at least 60 min (maximum rate of 10 mg/min for doses >500 mg) [21] due to the high incidence of pain and thrombophlebitis and to avoid an infusion reaction known as vancomycin flushing reaction. This phenomenon has been often clinically referred to as "red man syndrome".
A drug of last resort (DoLR), also known as a heroic dose, [1] is a pharmaceutical drug which is tried after all other drug options have failed to produce an adequate response in the patient. Drug resistance , such as antimicrobial resistance or antineoplastic resistance , may make the first-line drug ineffective, especially in case of ...
In single-dose scenarios, the patient's body weight and the drug's recommended dose per kilogram are used to determine a safe one-time dose. If multiple doses of treatment are needed in a day, the physician must take into account information regarding the total amount of the drug which is safe to use in one day, and how that should be broken up ...
Intense exercise lasting 20–45 minutes at least three time per week, or a job with a lot of walking, or a moderate intensity job. Very active 2.1 1.9 Intense exercise lasting at least an hour per day, or a heavy physical job, such as a mail carrier or an athlete in training. Extremely active 2.4 2.2
An example for a simple case (mono-compartmental) would be to administer D=8 mg/kg to a human. A human has a blood volume of around V b l o o d = {\displaystyle V_{blood}=} 0.08 L/kg . [ 7 ] This gives a C 0 = {\displaystyle C_{0}=} 100 μg/mL if the drug stays in the blood stream only, and thus its volume of distribution is the same as V b l o ...
Excess or reduced body weight is regarded as an indicator of determining a person's health, with body volume measurement providing an extra dimension by calculating the distribution of body weight. Average adult human weight varies by continent, from about 60 kg (130 lb) in Asia and Africa to about 80 kg (180 lb) in North America, with men on ...
The inhibition of exercise-induced skeletal muscle damage by HMB is affected by the time that it is used relative to exercise. [ 29 ] [ 33 ] The greatest reduction in skeletal muscle damage from a single bout of exercise appears to occur when calcium HMB is ingested 1–2 hours prior to exercise.