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Typhoid fever, also known simply as typhoid, is a disease caused by Salmonella enterica serotype Typhi bacteria, also called Salmonella Typhi. [2] [3] Symptoms vary from mild to severe, and usually begin six to 30 days after exposure. [4] [5] Often there is a gradual onset of a high fever over several days. [4]
Typhoid fever is caused by the bacterium Salmonella enterica Serovar Typhi. [ 37 ] In Canada alone, the typhus epidemic of 1847 killed more than 20,000 people from 1847 to 1848, mainly Irish immigrants in fever sheds and other forms of quarantine, who had contracted the disease aboard the crowded coffin ships in fleeing the Great Irish Famine .
Typhoid vaccines are vaccines that prevent typhoid fever. [1] [2] [3] Several types are widely available: typhoid conjugate vaccine (TCV), Ty21a (a live oral vaccine) and Vi capsular polysaccharide vaccine (ViPS) (an injectable subunit vaccine). They are about 30 to 70% effective in the first two years, depending on the specific vaccine in ...
The quarantining of people often raises questions of civil rights, especially in cases of long confinement or segregation from society, such as that of Mary Mallon (also known as Typhoid Mary), a typhoid fever carrier who was arrested and quarantined in 1907 and later spent the last 23 years and 7 months of her life in medical isolation at ...
Outbreaks of typhoid fever are also frequently reported from sub-Saharan Africa and countries in Southeast Asia. [5] [6] [7] In the United States, about 400 cases occur each year, and 75% of these are acquired while traveling internationally. [8] [9] Historically, before the antibiotic era, the case fatality rate of typhoid
Epidemic typhus, also known as louse-borne typhus, is a form of typhus so named because the disease often causes epidemics following wars and natural disasters where civil life is disrupted. [ 4 ] [ 5 ] Epidemic typhus is spread to people through contact with infected body lice , in contrast to endemic typhus which is usually transmitted by fleas .
Mary Mallon (September 23, 1869 – November 11, 1938), commonly known as Typhoid Mary, was an Irish-born American cook who is believed to have infected between 51 and 122 people with typhoid fever. The infections caused three confirmed deaths, with unconfirmed estimates of as many as 50.
A newer conjugate form of the vaccine (Vi bound to a non-toxic recombinant Pseudomonas aeruginosa exotoxin A, or Vi-rEPA) has enhanced efficacy, [3] including protection of children under 5 years of age. The typhoid conjugate vaccine ("Typbar-TCV") is another Vi-based conjugate vaccine, in this case linked to Tetanus toxoid. It has been ...