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Identify the mechanism of action of various low molecular weight heparin agents. Summarize the indications for using LMWH agents. Review the adverse event profiles of various LMWH agents, summarizing the key differences.
Low Molecular-Weight Heparin (LMWH) is a heterogeneous collection of heparin molecules with a lower average molecular weight compared to unfractionated heparin. Since longer length is necessary to facilitate the interaction between antithrombin III and factor IIa, LMWH is less effective at inhibiting factor IIa (acting mostly via inhibition of Xa).
Low-molecular-weight heparin (LMWH) is a class of anticoagulant medications. [1] They are used in the prevention of blood clots and, in the treatment of venous thromboembolism (deep vein thrombosis and pulmonary embolism), and the treatment of myocardial infarction.
Heparins, including unfractionated heparin and a variety of low molecular weight (LMW) heparin products, are used extensively as anticoagulants. This topic will review the general principles underlying the therapeutic use of unfractionated and LMW heparins including dosing, monitoring, and reversal of anticoagulation, as well as danaparoid (not ...
Two types of heparins are commonly used for DVT: unfractionated heparin (UFH) and low-molecular-weight heparin (LMWH). How They Work for DVT. The two types of heparin work in a similar way.
Low molecular weight heparin (LMWH) and fondaparinux (FDP) are frequently used to treat and prevent VTE and have a variety of safety and practical advantages over other anticoagulants, including use in outpatient settings.
The American College of Chest Physicians (ACCP) recommends using heparin for many other thrombotic states: atrial fibrillation undergoing cardioversion, endocarditis, systemic emboli, or venous thrombosis. [3] [4] Dosing recommendations vary for each indication.
The anti–factor Xa assay is designed to measure plasma heparin (unfractionated heparin [UH] and low molecular weight heparin [LMWH]) levels and to monitor anticoagulant therapy.
Comparison of low-molecular-weight heparin, administered primarily at home, with unfractionated heparin, administered in hospital, and subcutaneous heparin, administered at home for deep-vein thrombosis
Heparin and its derivative, low-molecular-weight heparin (LMWH), are the anticoagulants of choice when a rapid anticoagulant effect is required because their onset of action is immediate when administered by IV injection.