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One example is the Suzuki reaction where, in the presence of a Pd(0) catalyst and base, phenylboronic acid and vinyl halides are coupled to produce phenyl alkenes. [7] This method was generalized to a route producing biaryls by coupling phenylboronic acid with aryl halides. C-C bond forming processes commonly use phenylboronic acid as a reagent.
It can be prepared by a Suzuki-Miyaura coupling from the 4-trifluoromethylphenylboronic acid. [2] Complementarily, it can be produced by trifluoromethylation of 4-formylphenylboronic acid. [3] It readily condenses with amines to give imines. [4] It has been used in the synthesis of pharmaceuticals, such as Lanperisone. [5]
4-Formylphenyl boronic acid crystallizes in colorless needles [2] or is obtained as an odorless, whitish powder, which dissolves little in cold but better in hot water. The compound is quite stable [4] and readily forms dimers and cyclic trimeric anhydrides, which complicate purification and tend to protodeboronize, a secondary reaction that occurs frequently in the Suzuki coupling, with ...
4-Nonylphenylboronic acid is a potent and selective inhibitor of the enzyme fatty acid amide hydrolase (FAAH), with an IC 50 of 9.1nM, and 870x selectivity for FAAH over the related enzyme MAGL, which it inhibits with an IC 50 of 7900nM. [1]
1-Boc-4-AP (tert-butyl 4-(phenylamino)piperidine-1-carboxylate) is a compound used as an intermediate in the manufacture of fentanyl, as well as various related derivatives such as butyrylfentanyl, furanylfentanyl, benzylfentanyl and homofentanyl, among others.
4-Methylphenethylamine (4MPEA), also known as para-methylphenethylamine, is an organic compound with the chemical formula of C 9 H 13 N.4MPEA is a human trace amine associated receptor 1 (TAAR1) agonist, [2] a property which it shares with its monomethylated phenethylamine isomers, such as amphetamine (α-methylphenethylamine), β-methylphenethylamine, and N-methylphenethylamine (a trace amine).
Aminomethylbenzoic acid (more precisely, 4-aminomethylbenzoic acid or p-aminomethylbenzoic acid, PAMBA) is an antifibrinolytic. [1] See also. 4-Aminobenzoic acid;
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