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Prothrombin gene mutation (or Factor II mutation or Prothrombin G20210A) is an inherited condition that increases your predisposition to develop abnormal blood clots in the veins (deep vein thrombosis or DVT) and lungs (pulmonary embolism or PE).
Prothrombin G20210A is a genotypic trait that provides a prompter coagulation response. It increases the risk of blood clots including from deep vein thrombosis, and of pulmonary embolism. [1] One copy of the mutation increases the risk of a blood clot from 1 in 1,000 per year to 2.5 in 1,000. [1]
Heterozygous prothrombin mutations are found in about 2% of the US white population. The mutation is uncommon in African Americans (approximately 0.5%) and is rare in Asians, Africans, and Native Americans.
Prothrombin 20210 Mutation, also called Factor II Mutation is a genetic condition that causes an increase in the likelihood of your blood forming dangerous blood clots. All individuals make the prothrombin (also called factor two) protein that helps blood clot.
The prothrombin gene mutation G20210A results from a change in a single nucleotide (a DNA building block). It causes your cells to produce too much prothrombin, which can lead to excessive...
Prothrombin thrombophilia is inherited in an autosomal dominant manner: heterozygosity for the 20210G>A variant results in an increased risk for thrombosis; homozygosity for this variant confers a higher risk for thrombosis than heterozygosity.
To research the association of prothrombin (factor II) activity given the prothrombin G20210A mutation carriage with its clinical manifestations as thrombotic complications. A prospective clinical cohort study of 290 women of reproductive age was conducted.
A single nucleotide mutation in one (or, less commonly, both) of the prothrombin genes at position 20210 results in increased plasma prothrombin levels (with potentially increased thrombin generation) and increases the risk of venous thromboembolism (VTE).
A prothrombin gene mutation is the second most common congenital thrombophilias and considered to be associated with arterial or venous thrombosis risk. Heterozygous and homozygous mutations are the two possible genotypic presentations.
What to Know About Prothrombin (Factor II) Gene Mutation. Learn about the role of the prothrombin gene and how a mutation in this gene can increase your risk of thrombosis and other...