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With intramuscular injections of estradiol valerate, it has been reported that a dose of 5 mg has a duration of 7 to 8 days, 10 mg a duration of 10 to 14 days, 40 mg a duration of 2 to 3 weeks (14 to 21 days), and 100 mg a duration of 3 to 4 weeks (21 to 28 days).
0.4 1 1 1 Vaginal : 0.5 1.0: 3 h 3 h +830 ... A single administration of 4 mg ... the medication can be administered multiple times per day in divided doses to ...
Estradiol is an estrogen, or an agonist of the nuclear estrogen receptors (ERs), the estrogen receptor alpha (ERα) and the estrogen receptor beta (ERβ). [1] [2] [6] In one study, the EC 50 Tooltip half-maximal effective concentration value of estradiol for the human ERα was 50 pM (0.05 nM) and for the human ERβ was 200 pM (0.2 nM).
The researchers reported that 400 mg of caffeine is roughly equivalent to four cups of coffee, 10 cans of soda, or two energy drinks. They reported that nearly 20% of the study participants ...
Researchers found that those consuming more than 400 mg of caffeine daily had elevated heart rates and blood pressure. This effect was even more pronounced in those consuming over 600 mg daily ...
Maximum recommended daily caffeine intake 4–6 45 mg (slightly more than in 355 ml (12 fl. oz) of a typical caffeinated soft drink) 7–9 62.5 mg 10–12
These symptoms including nervousness, irritability, restlessness, insomnia, headaches, and palpitations after caffeine use. [4] Caffeinism usually occurs when consumption of caffeine reaches 1–1.5 grams (0.035–0.053 oz) per day. [5] For reference, a brewed 8oz (227ml) cup of coffee contains ~95 mg of caffeine (per USDA). [6]
Free caffeic acid can be found in a variety of beverages, including brewed coffee at 63.1-96.0 mg per 100 ml [7] and red wine at 2 mg per 100 ml. [8] It is found at relatively high levels in herbs of the mint family, especially thyme, sage and spearmint (at about 20 mg per 100 g), and in spices, such as Ceylon cinnamon and star anise (at about 22 mg per 100 g).