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Pyridoxine/doxylamine, sold under the brand name Diclectin among others, is a combination of pyridoxine hydrochloride (vitamin B 6) and doxylamine succinate.It is generally used for nausea and vomiting of pregnancy (morning sickness); even though its efficacy has not been proven and subsequent research has led to the removal of recommendations in medical journals.
Doxylamine succinate is the active ingredient in many over-the-counter sleep aids branded under various names. Doxylamine succinate and pyridoxine (Vitamin B6) are the ingredients of Diclegis, approved by the FDA in April 2013 becoming the only drug approved for morning sickness [46] with a class A safety rating for pregnancy (no evidence of risk).
Although described as "morning sickness," pregnant women can experience this nausea any time of day or night. The exact cause of morning sickness remains unknown. Nausea and vomiting in pregnancy is typically mild and self-limited, resolving on its own by the 14th week of pregnancy. Other causes should also be ruled out when considering treatment.
Some have proposed that morning sickness may be useful from an evolutionary point of view. [1] Diagnosis should only occur after other possible causes have been ruled out. [3] Abdominal pain, fever, or headaches are typically not present in morning sickness. [1] Morning sickness affects about 70–80% of all pregnant women to some extent.
Previous studies have suggested sickness and nausea in pregnancy could relate to GDF15 being produced by the placenta, but researchers said the “full mechanistic understanding is lacking”.
According to a study conducted by Whitcome, et al., lumbar lordosis can increase from an angle of 32 degrees at 0% fetal mass (i.e. non-pregnant women or very early in pregnancy) to 50 degrees at 100% fetal mass (very late in pregnancy). Postpartum, the angle of the lordosis declines and can reach the angle prior to pregnancy.
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