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CSL was founded in 1916 as Commonwealth Serum Laboratories, an Australian government body focused on vaccine manufacture. [4] Under the first director, William Penfold, [5] CSL commenced operation in the vacant Walter and Eliza Hall Institute building at the Royal Melbourne Hospital in 1918 before moving to its purpose-built Parkville premises in the following year.
CSL Plasma is a subsidiary of its sister company CSL Behring, itself a subsidiary of CSL Limited, a biotechnology company based in Melbourne, Australia. [2] [ P 2] It is headquartered in Boca Raton, Florida, [1] and operates a total of 320 collection centers in the United States, [P 3] and a further 19 more in other nations including China, Hungary, and Germany as of 2023.
CSL Behring is a biopharmaceutical company, manufacturing plasma-derived and recombinant therapeutic products. [2] The company is a combination of Behringwerke, founded in 1904 in Marburg, Germany by Emil von Behring, and the Commonwealth Serum Laboratories (CSL), established in Australia in 1916 to provide vaccines to the people of Australia, as well as other companies acquired since 2004.
The 2000 CDC growth charts - a revised version of the 1977 NCHS growth charts - are the current standard tool for health care providers and offer 16 charts (8 for boys and 8 for girls), of which BMI-for-age is commonly used for aiding in the diagnoses of childhood obesity. [1]
The procedure is to take the child's weight in pounds, divide by 150 lb, and multiply the fractional result by the adult dose to find the equivalent child dosage.For example, if an adult dose of medication calls for 30 mg and the child weighs 30 lb, divide the weight by 150 (30/150) to obtain 1/5 and multiply 1/5 times 30 mg to get 6 mg.
The blood volume is 70 ml/kg body weight in adult males, 65 ml/kg in adult females and 70-75 ml/kg in children (1 year old and over). [ 5 ] [ 6 ] Total Blood Volume has been measured manually by the use of carbon monoxide (CO) as a tracer for more than 100 years and was first proposed by French scientists Grehant and Quinquaud in 1882.
There are two commercially available Factor X concentrates: "Factor X P Behring" manufactured by CSL Behring, [10] and high purity Factor X Coagadex produced by Bio Products Laboratory and approved for use in the United States by the FDA in October 2015, and in the EU in March 2016, after earlier acceptance by CHMP and COMP. [11] [12] [13] [14]
For a given solution, osmolarity is slightly less than osmolality, because the total solvent weight (the divisor used for osmolality) excludes the weight of any solutes, whereas the total solution volume (used for osmolarity) includes solute content. Otherwise, one litre of plasma would be equivalent to one kilogram of plasma, and plasma ...