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Ethosuximide, sold under the brand name Zarontin among others, is a medication used to treat absence seizures. [4] It may be used by itself or with other antiseizure medications such as valproic acid. [4] Ethosuximide is taken by mouth. [4] Ethosuximide is usually well tolerated. [5]
Absence seizures are also known to occur to patients with porphyria and can be triggered by stress or other porphyrin-inducing factors. Childhood Absence Epilepsy. Childhood absence epilepsy (CAE) is a type of idiopathic epilepsy characterized by its non-convulsive, generalized nature and a genetic origin influenced by multiple factors [20]
Therefore, almost all new epilepsy drugs are initially approved only as adjunctive (add-on) therapies. Patients whose epilepsy is uncontrolled by their medication (i.e., it is refractory to treatment) are selected to see if supplementing the medication with the new drug leads to an improvement in seizure control.
The pathophysiology of absence seizures has been linked to oscillatory thalamic-cortical potentials, calcium currents, and the interaction of GABAergic neurons. It seems clear that the pathophysiology of absence seizures differs from other epilepsies which may, in part, explain the unique efficacy of ethosuximide in this syndrome.
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The first-line treatments for childhood absence epilepsy, valproate and ethosuximide, are both blockers of T-type calcium channels; the second-line treatment, lamotrigine, although not a T-type calcium channel blocker, does inhibit high-voltage activated calcium channels.
Ryan Beeler and his wife, Melissa, flew from their home in Oklahoma to New York City to celebrate his 40th birthday. Before they went, the couple decided to watch Elf to get into the holiday ...
Pomeroy has used similar methods to track season-long conference strength since 1997. So far only the 1996-97 ACC and the 2003-04 ACC outrate this year’s SEC. So far only the 1996-97 ACC and the ...
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