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Weight machines use gravity as the primary source of resistance, and a combination of simple machines to convey that resistance, to the person using the machine. Each of the simple machines (pulley, lever, wheel, incline) changes the mechanical advantage of the overall machine relative to the weight.
Astronaut Kjell Lindgren exercises using the ARED. The Advanced Resistive Exercise Device (ARED) is an exercise device designed by NASA to allow for more intense workouts in zero gravity.