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Chloroquine and hydroxychloroquine are anti-malarial medications also used against some auto-immune diseases. [65] Chloroquine, along with hydroxychloroquine, was an early experimental treatment for COVID-19. [66] Neither drug has been useful to prevent or treat SARS-CoV-2 infection.
This list of over 500 monoclonal antibodies includes approved and investigational drugs as well as drugs that have been withdrawn from market; consequently, the column Use does not necessarily indicate clinical usage.
Examples include amodiaquine, chloroquine, and hydroxychloroquine. [3] Other uses for the derivatives are: anti-asthmatic, antibacterial, anti-fungal, anti-malarial, antiviral and anti-inflammatory agents. [1] A patent application for 4-aminoquinoline compounds was filed in 2002 and published in 2005. [4]
Chloroquine and hydroxychloroquine are anti-malarial medications also used against some auto-immune diseases. [51] Chloroquine, along with hydroxychloroquine, was an early experimental treatment for COVID-19. [52] Neither drug has been useful to prevent or treat SARS-CoV-2 infection.
Non-small cell lung cancer, oesophageal cancer, uterine cervical cancer, head and neck cancer and urothelial cancer: Nephrotoxicity, myelosuppression and nausea and vomiting (30-90%). Oxaliplatin: IV: Reacts with DNA, inducing apoptosis, non-cell cycle specific. Colorectal cancer, oesophageal cancer and gastric cancer
For example, methotrexate is used as cancer chemotherapy because it can prevent neoplastic cells from dividing. [1] [2] Bacteria also need DHFR to grow and multiply and hence inhibitors selective for bacterial vs. host DHFR have found application as antibacterial agents. [3] Tetrahydrofolate synthesis pathway
As a result, the entire antibody, linker and cytotoxic (anti-cancer) agent enter the targeted cancer cell where the antibody is degraded into an amino acid. The resulting complex – amino acid, linker and cytotoxic agent – is considered to be the active drug. In contrast, cleavable linkers are detached by enzymes in the cancer cell. The ...
Chloroquine and hydroxychloroquine are anti-malarial medications also used against some auto-immune diseases. [1] Chloroquine, along with hydroxychloroquine, was an early experimental treatment for COVID-19. [2] Neither drug has been useful to prevent or treat SARS-CoV-2 infection.