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The feature of the axolotl that attracts most attention is its healing ability: the axolotl does not heal by scarring and is capable of the regeneration of entire lost appendages in a period of months, and, in certain cases, more vital structures, such as tail, limb, central nervous system, and tissues of the eye and heart. [29]
The axolotl can grow up to 12 inches and weigh anywhere from three to eight pounds, and its average lifespan in the wild is 10-15 years. Most axolotls are dark brown with some black speckling, but ...
The axolotl salamander Ambystoma mexicanum, an organism with exceptional limb regenerative capabilities, likely undergoes epigenetic alterations in its blastema cells that enhance expression of genes involved in limb regeneration. The Axolotl has very little blood and has an excess of epidermal cells.
During the 1990s, published research on the subject increased; it is a relatively recent term in the literature. Scar free healing occurs in foetal life but the ability progressively diminishes into adulthood. In other animals such as amphibians, however, tissue regeneration occurs, for example as skin regeneration in the adult axolotl. [1]
A study from 1998 found there were 6000 wild axolotls. Now biologists say they can barely find them ... That's because the amphibian can regenerate brains, jaws and even spines without scarring.
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Hox genes play a massive role in some amphibians and reptiles in their ability to regenerate lost limbs, especially HoxA and HoxD genes. [1]If the processes involved in forming new tissue can be reverse-engineered into humans, it may be possible to heal injuries of the spinal cord or brain, repair damaged organs and reduce scarring and fibrosis after surgery.
The axolotl is less commonly used than other vertebrates, but is still a classical model for examining regeneration and neurogenesis. Though the axolotl has made its place in biomedical research in terms of limb regeneration, [19] [20] the model organism has displayed a robust ability to generate new neurons following damage.