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This condition used to be called "male pseudohermaphroditism". This is defined as incomplete masculinization of the external genitalia. [204] Thus, the person has male chromosomes, but the external genitals are incompletely formed, ambiguous, or clearly female. [197] [205] This condition is also called 46, XY with undervirilization.
Intersex people are born with sex characteristics, such as genitals, gonads and chromosome patterns that, according to the UN Office of the High Commissioner for Human Rights, "do not fit the typical definitions for male or female bodies". [1] [2]
Males typically have two different kinds of sex chromosomes (XY), and are called the heterogametic sex. [1] In humans, the presence of the Y chromosome is responsible for triggering male development; in the absence of the Y chromosome, the fetus will undergo female development.
The tip of the Y chromosome contains the SRY gene and, during recombination, a translocation occurs in which the SRY gene becomes part of the X chromosome. [15] [26] If a fetus is conceived from a sperm cell with an X chromosome bearing the SRY gene, it will develop as a male despite not having a Y chromosome. This form of the condition is ...
Intersex, in humans and other animals, describes variations in sex characteristics including chromosomes, gonads, sex hormones, or genitals that, according to the UN Office of the High Commissioner for Human Rights, "do not fit typical binary notions of male or female bodies".
She told Good Morning Britain, "Genetically, I have XY chromosomes so the genetic makeup of a man, but physically I grew as a woman because the Y chromosome was faulty. I am a woman, I just didn't ...
However, when an extra DAX1 gene is placed on the X chromosome, the result is a female, despite the existence of SRY, since it overrides the effects of SRY. [11] Even when there are normal sex chromosomes in XX females, duplication or expression of SOX9 causes testes to develop.
Intersex people are born with natural variations in physical and sex characteristics including those of the chromosomes, gonads, sex hormones, or genitals that, according to the UN Office of the High Commissioner for Human Rights, "do not fit the typical definitions for male or female bodies".