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5α-reductase deficiency (5-ARD) – an autosomal recessive condition caused by a mutation of the 5-alpha reductase type 2 gene. It only affects people with Y chromosomes, namely genetic males. People with this condition are fertile, with the ability to father children, but may be raised as females due to ambiguous or feminized genitalia. [18] [19]
The human Y chromosome showing the SRY gene which codes for a protein regulating sexual differentiation. Sexual differentiation in humans is the process of development of sex differences in humans. It is defined as the development of phenotypic structures consequent to the action of hormones produced following gonadal determination. [1]
[1]: 25 Prenatal factors that affect or interfere with the interaction of these hormones on the developing brain can influence later sex-typed behavior in children. [ 1 ] : 24 This hypothesis is originated from experimental studies in non-human mammals, yet the argument that similar effects can be seen in human neurobehavioral development is a ...
Although there is a wide range of normal ages, females typically begin the process of puberty around age 10½; males at ages 11½—12. Puberty generally ends between 15—17 for females and 16–17 for males. [1] [2] [3] Females attain reproductive maturity about four years after the first physical changes of puberty appear. [13]
This is an accepted version of this page This is the latest accepted revision, reviewed on 6 January 2025. Procreative biological processes of humanity Part of a series on Sex Biological terms Sexual dimorphism Sexual differentiation Feminization Virilization Sex-determination system XY XO ZW ZO Temperature-dependent Haplodiploidy Heterogametic sex Homogametic sex Sex chromosome X chromosome Y ...
Infants born with atypical genitalia often cause confusion and distress for the family. Psychosexual development is influenced by numerous factors that include, but are not limited to, gender differences in brain structure, genes associated with sexual development, prenatal androgen exposure, interactions with family, and cultural and societal ...
Mood Changes. Not only does testosterone affect many physiological processes, but it can also have an impact on cognitive function and mood. ... Klinefelter’s syndrome occurs when a man is born ...
In 5α-Reductase 2 deficiency, individuals are born with normal female genitalia, however, during puberty, male differentiation and spermatogenesis occurs. Partial genital undermasculinization can occur if the body has a partial resistance to androgens , or if genital development is blocked, undermasculization can also be induced by certain ...