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It was banned in India in 1998. [37] Fenfluramine was an appetite suppressant which was used to treat obesity. [8] It was used both on its own and, in combination with phentermine, as part of the anti-obesity medication Fen-Phen. [8] In June 2020, fenfluramine was approved for medical use in the United States with an indication to treat Dravet ...
Fenfluramine as a single drug was first introduced in the 1970s, but was not popular because it only temporarily reduced weight. [1] A 1984 study found a weight loss of 7.5 kg on average in 24 weeks, as compared to 4.4 kg under placebo. [4] It sold modestly until the 1990s, when it was combined with phentermine and heavily marketed.
After several reports of adverse cardiovascular effects, the FDA banned dexfenfluramine in 1997. [12] [17] [18] It appears that the 5-HT 2B receptors, expressed in cardiac valves, are responsible for the valvulopathies reported from the use of fenfluramine and dexfenfluramine. [19]
Andro, DHEA, stanozolol, testosterone, and nandrolone, or derivates (see below) are banned anabolic steroids. Other banned anabolic agents include clenbuterol, tibolone, zeranol, zilpaterol, and selective androgen receptor modulators. [7] While a few of the banned drugs are endogenous, that is they are normally produced in the human body, most ...
Phentermine was marketed with fenfluramine or dexfenfluramine as a combination appetite suppressant and fat burning agent under the popular name fen-phen. [18] In 1997, after 24 cases of heart valve disease in fen-phen users, fenfluramine and dexfenfluramine were voluntarily taken off the market at the request of the FDA. [19]
While rainbow diet pills were banned in the US in the late 1960s, they reappeared in South America and Europe in the 1980s. [38] In 1959, phentermine had been FDA approved and fenfluramine in 1973. In the early 1990s two studies found that a combination of the drugs was more effective than either on its own; fen-phen became popular in the ...
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Anorectic. An anorectic is a drug which reduces appetite, resulting in lower food consumption, leading to weight loss. [1] These substances work by affecting the central nervous system or certain neurotransmitters to create a feeling of fullness or reduce the desire to eat. The understanding of anorexiant effects is crucial in the development ...
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