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Epstein–Barr virus. Epstein–Barr virus (EBV) is a member of the gammaherpesvirus subfamily. EBV is responsible for infectious mononucleosis and is linked to several forms of cancer. EBV infects both B cells and epithelial cells and is able to undergo latency in both of these cells. A remarkable fact concerning the latency of EBV is that ...
In the case of varicella zoster virus, after an initial acute infection the virus lies dormant until reactivated as herpes zoster. More serious ramifications of a latent infection could be the possibility of transforming the cell, and forcing the cell into uncontrolled cell division. This is a result of the random insertion of the viral genome ...
The Epstein–Barr virus (EBV) is one of the nine known human herpesvirus types in the herpes family, and is one of the most common viruses in humans. EBV is a double-stranded DNA virus and is also called human herpesvirus 4 (HHV-4). [2] Epstein–Barr virus (EBV) is the first identified oncogenic virus, or a virus that can cause cancer. EBV ...
Reactivation of latent viruses has been implicated in a number of diseases (e.g. shingles, pityriasis rosea). Following activation, transcription of viral genes transitions from LAT to multiple lytic genes; these lead to enhanced replication and virus production. Often, lytic activation leads to cell death.
Hydroa vacciniforme is commonly associated with reactivation of a latent Epstein–Barr virus (EBV) formerly acquired by an asymptomatic or infectious mononucleosis-causing infection. It is therefore classified as one of the Epstein–Barr virus–associated lymphoproliferative diseases and termed EBV+ HV.
Epstein–Barr virus latent membrane protein 1 (LMP1) is an Epstein–Barr virus (EBV) protein that regulates its own expression and the expression of human genes. [1] It has a molecular weight of approximately 63 kDa, and its expression induces many of the changes associated with EBV infections and activation of primary B cells. [2]
Lytic infection is sometimes known as "productive" infection. Latent cells harbor the virus for long time periods, then occasionally convert to productive infection which may lead to a recurrence of symptomatic Herpes symptoms. During latency, most of the Herpes DNA is inactive, with the exception of LAT, which accumulates within infected cells.
Latent infections are "dormant", meaning no active virions are produced, however the virus generates proteins and RNAs to modulate host-virus interactions that maintain latent infection. In ways yet to be fully determined, these interactions make EBV-infected B cells more prone to becoming cancerous (e.g. Hodgkin's lymphoma , Burkitt's lymphoma ...