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The cell cycle.Many tumor suppressors work to regulate the cycle at specific checkpoints in order to prevent damaged cells from replicating. A tumor suppressor gene (TSG), or anti-oncogene, is a gene that regulates a cell during cell division and replication. [1]
Cancer is a genetic disease caused by accumulation of DNA mutations and epigenetic alterations leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers and new ...
Replication of DNA in such cells leads to mutations and these mutations may cause cancer. Thus BRCA1 appears to have two roles related to the prevention of cancer, where one role is to promote repair of a specific class of damages and the second role is to induce apoptosis if the level of such DNA damage is beyond the cell's repair capability [69]
Cancer prevention is the practice of taking active measures to decrease the incidence of cancer and mortality. [ 1 ] [ 2 ] The practice of prevention depends on both individual efforts to improve lifestyle and seek preventive screening , and socioeconomic or public policy related to cancer prevention. [ 3 ]
Newborn genetic screening is a promising area in public health genomics that appears poised to capitalize on the public health goal of disease prevention as a primary form of treatment. Most of the diseases that are screened for are extremely rare, single-gene disorders that are often autosomal recessive conditions and are not readily ...
Cervical cancer is the fourth most common cancer for women with an estimated 340,000 deaths according to the World Health Organization (WHO). [27] HPV disease is the leading cause of cervical cancer, therefore making the HPV vaccine the primary prevention measure for the cancer.
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Most cases of lung cancer are because of genetic mutations in EGFR, KRAS, STK11 (also known as LKB1), TP53 (also known as p53), and CDKN2A (also known as p16 or INK4a) [117] [118] [119] with the most common type of lung cancer being an inactivation at p16. p16 is a tumor suppressor protein that occurs in mostly in humans the functional ...