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Excessive QT prolongation can trigger tachycardias such as torsades de pointes (TdP). QT prolongation is an established side effect of antiarrhythmics, but can also be caused by a wide range of non-cardiac medicines, including antibiotics, antidepressants, antihistamines, opioids, and complementary medicines.
Prior to administration of the first dose, the corrected QT (QTc) must be determined. If the QTc is greater than 440 msec (or 500 msec in patients with ventricular conduction abnormalities), dofetilide is contraindicated. If heart rate is less than 60 bpm, the uncorrected QT interval should be used. After each subsequent dose of dofetilide, QTc ...
Topiramate, sold under the brand name Topamax among others, is a medication used to treat epilepsy and prevent migraines. [9] It has also been used in alcohol dependence and essential tremor. [9] For epilepsy this includes treatment for generalized or focal seizures. [10] It is taken orally (by mouth). [9]
Have kidney problems, including kidney stones. Have liver problems. Have osteoporosis (weak or brittle bones) ... Topiramate side effects exist. And they go beyond weight loss. Look out for ...
QT prolongation and phototoxicity. [2] Sulfacarbamide: 1988 Germany Dermatologic, hematologic and hepatic reactions. [3] Sulfamethoxydiazine: 1988 Germany Unknown. [3] Sulfamethoxypyridazine: 1986 UK Dermatologic and hematologic reactions. [3] Suloctidil: 1985 Germany, France, Spain Hepatotoxicity. [3] Suprofen: 1986–1987 UK, Spain, US Kidney ...
Long QT syndrome (LQTS) is a condition affecting repolarization (relaxing) of the heart after a heartbeat, giving rise to an abnormally lengthy QT interval. [7] It results in an increased risk of an irregular heartbeat which can result in fainting, drowning, seizures, or sudden death. [1]
Priapism is a non-intimate prolonged arousal that isn’t relieved by climax. It is a serious medical emergency that can cause pain, lasting damage to the privates and permanent dysfunction if it ...
The cardiac features of JLNS can be diagnosed by measuring the QT interval corrected for heart rate (QTc) on a 12-lead electrocardiogram (ECG). The QTc is less than 450 ms in 95% of normal males, and less than 460 ms in 95% of normal females. In those with Jervell and Lange-Nielsen syndrome the QTc is typically greater than 500 ms. [8]