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In early 1900s, there was a growing need for advancement in applied sciences in the United Provinces of Agra and Oudh (erstwhile NWP) of British India.On the initiative of ICS officer Sir Spencer H. Butler, [8] the Conference on Industrial Development at Nainital summoned in 1907 by the then Lieutenant-Governor of the province, [9] Sir John P. Hewett, GCSI, KBE, CIE, GCStJ, recommended the ...
HBTU (Hexafluorophosphate Benzotriazole Tetramethyl Uronium) is a coupling reagent used in solid phase peptide synthesis. It was introduced in 1978 and shows resistance against racemization. It was introduced in 1978 and shows resistance against racemization.
HCTU is an amidinium coupling reagent used in peptide synthesis.It is analogous to HBTU. [1] The HOBt moiety has a chlorine in the 6 position which improves reaction rates and the synthesis of difficult couplings [2] [3] HCTU and related reagents containing the 6-chloro-1-hydroxybenzotriazole moiety can be prepared by reaction with TCFH under basic conditions. [4]
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