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Orally-administered Oxytocin has been shown to increase putamen responses to facial emotions in humans. [42] Oxytocin administered orally produces different effects on human behaviour and brain function than when given intranasally, possibly due to variations in the molecular transport and binding mechanisms.
Nasally administered oxytocin has been reported to reduce fear, possibly by inhibiting the amygdala (which is thought to be responsible for fear responses). [120] Indeed, studies in rodents have shown oxytocin can efficiently inhibit fear responses by activating an inhibitory circuit within the amygdala.
Calcium-channel blockers (such as nifedipine) and oxytocin antagonists (such as atosiban) may delay delivery by 2 to 7 days, depending on how quickly the medication is administered. [45] NSAIDs (such as indomethacin ) and calcium channel blockers (such as nifedipine ) are the most likely to delay delivery for 48 hours, with the least amount of ...
It is given intravenously since it is easily degraded by the body if given orally. While giving oxytocin, it is important to monitor the mother and the fetus, specifically the mother's uterine activity and the fetal heart rate. The more common side effects of oxytocin include tachysystole, hyponatremia, and hypotension. Tachysystole is an ...
In many women given epidural analgesia during labor oxytocin is also used to augment uterine contractions. In one study which examined the rate of breastfeeding two days following epidural anesthesia during childbirth, epidural analgesia used in combination with oxytocin resulted in lower maternal oxytocin and prolactin levels in response to ...
Oxytocin/ergometrine (trade name Syntometrine) is an obstetric combination drug. The components are synthetically produced oxytocin , a human hormone produced in the hypothalamus , and ergometrine , an alpha-adrenergic , dopaminergic and serotonin (5-HT 2 ) receptor agonist.
Pitocin, a synthetic version of oxytocin, is often administered to induce labour. Oxytocin is a natural hormone and a uterotonic agent which stimulates the uterine muscles to contract and initiate labour. [18] Cesarean section is also commonly considered when the pregnancy fails to progress. [19]
Routes of administration are usually classified by application location (or exposition). The route or course the active substance takes from application location to the location where it has its target effect is usually rather a matter of pharmacokinetics (concerning the processes of uptake, distribution, and elimination of drugs).