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[2] [3] Mastoiditis is usually caused by untreated acute otitis media (middle ear infection) and used to be a leading cause of child mortality. With the development of antibiotics, however, mastoiditis has become quite rare in developed countries where surgical treatment is now much less frequent and more conservative, unlike former times. [2]
Bezold's abscess is an abscess deep to the sternocleidomastoid muscle where pus from mastoiditis erodes through the cortex of the mastoid part of the temporal bone, medial to the attachment of sternocleidomastoid, extends into the infratemporal fossa, and deep to the investing layer of the deep cervical fascia.
Gradenigo's syndrome, also called Gradenigo-Lannois syndrome, [1] [2] is a complication of otitis media and mastoiditis involving the apex of the petrous temporal bone. It was first described by Giuseppe Gradenigo in 1904. [3]
The above statistical analysis is dated, necessarily. A 2015 study of young adult students presenting to a single clinic in Alabama had F. necrophorum as the predominant causative organism for pharyngitis 21% of the time (and found in 9% of asymptomatic students). [11]
A mastoidectomy is a procedure performed to remove the mastoid air cells [1] near the middle ear. The procedure is part of the treatment for mastoiditis, chronic suppurative otitis media or cholesteatoma. [2] Additionally, it is sometimes performed as part of other procedures, such as cochlear implants, [3] or to access the middle ear.
Dicloxacillin is a narrow-spectrum β-lactam antibiotic of the penicillin class. [1] It is used to treat infections caused by susceptible (non-resistant) Gram-positive bacteria . [ 1 ] It is active against beta-lactamase -producing organisms such as Staphylococcus aureus , which would otherwise be resistant to most penicillins .
Brilacidin (formerly PMX-30063 [2]), an investigational new drug, is a polymer-based antibiotic currently in human clinical trials, and represents a new class of antibiotics called host defense protein mimetics, or HDP-mimetics, which are non-peptide synthetic small molecules modeled after host defense peptides (HDPs).
Staphylococcus capitis TE8 was isolated from the skin surface of a healthy adult foot and found to have potent antibacterial action against Gram-positive bacteria such as Staphylococcus aureus. [5] Staphylococcus is a gram-positive bacterial spherule. Some staphylococci are capable of producing free coagulase.