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Hereditary equine regional dermal asthenia. Hereditary equine regional dermal asthenia (HERDA), also known as hyperelastosis cutis (HC), is an inherited autosomal recessive connective tissue disorder. It develops from a homozygous recessive mutation that weakens collagen fibers that allow the skin of the animal to stay connected to the rest of ...
Hyperkalemic periodic paralysis (HYPP, HyperKPP) is a genetic disorder that occurs in horses. It is also known as Impressive syndrome, after an index case in a horse named Impressive. It is an inherited autosomal dominant disorder that affects sodium channels in muscle cells and the ability to regulate potassium levels in the blood.
Myosin-heavy chain myopathy (MYHM) is a genetic muscle disease found primarily in the American Quarter Horse and crossbred horses with significant Quarter Horse bloodlines. It was added to the AQHA genetic testing panel in 2022. [1] It is a genetic dominant condition, though not all horses who inherit the gene will show clinical signs of being ...
First symptoms are usually muscular weakness, soreness and stiffness causing problems with walking and breathing. Within hours of first symptoms horse may be unable to stand and in 72 hours of the onset of signs mortalities may occur. [16] [13] [1] The mortality rate of atypical myopathy is high; only 30-40% of affected horses survive. [9]
Equine exertional rhabdomyolysis (ER) is a syndrome that affects the skeletal muscles within a horse. This syndrome causes the muscle to break down which is generally associated with exercise and diet regime. Depending on the severity, there are various types of ER, including sporadic (i.e., Tying-Up, Monday Morning Sickness/Disease, Azoturia ...
Degenerative suspensory ligament desmitis. Degenerative suspensory ligament desmitis, commonly called DSLD, also known as equine systemic proteoglycan accumulation (ESPA), is a systemic disease of the connective tissue of the horse and other equines. It is a disorder akin to Ehlers–Danlos syndrome being researched in multiple horse breeds.
The Belgian Draft Horse is one breed in which JEB occurs. Junctional epidermolysis bullosa (JEB) is an inherited disorder that is also known as red foot disease or hairless foal syndrome. [1] JEB is the result of a genetic mutation that inhibits protein production that is essential for skin adhesion. [2] Therefore, tissues, such as skin and ...
Chronic progressive lymphedema (CPL) is a disease of some breeds of draft horse, whereby the lower legs becomes progressively more swollen. [1] There is no cure; [1] the aim of treatment is to manage the signs and slow progression of the disease. [2] The cause of CPL is not known, although it is suspected that a genetic disorder of elastin ...
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