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Cilostazol, sold under the brand name Pletal among others, is a medication used to help the symptoms of intermittent claudication in peripheral vascular disease. [ 2 ] If no improvement is seen after 3 months, stopping the medication is reasonable. [ 3 ] It may also be used to prevent stroke. [ 2 ] It is taken by mouth.
Clinical approaches on how to overcome clopidogrel resistance include higher doses of clopidogrel, concomitant use with the phosphodiesterase inhibitor cilostazol or switching to a new antiplatelet agent such as prasugrel and ticagrelor. Still, the major concern with these methods above are increased risk of bleeding.
Antiplatelet drug. An antiplatelet drug (antiaggregant), also known as a platelet agglutination inhibitor or platelet aggregation inhibitor, is a member of a class of pharmaceuticals that decrease platelet aggregation [1] and inhibit thrombus formation. They are effective in the arterial circulation where classical Vitamin K antagonist ...
Cangrelor. ~97–98%. Cangrelor, sold under the brand name Kengreal among others, is a P2Y 12 inhibitor FDA approved as of June 2015 as an antiplatelet drug [ 5 ] for intravenous application. Some P2Y 12 inhibitors are used clinically as effective inhibitors of adenosine diphosphate -mediated platelet activation and aggregation. [ 5 ]
Clopidogrel, sold under the brand name Plavix among others, is an antiplatelet medication used to reduce the risk of heart disease and stroke in those at high risk. [ 10 ] It is also used together with aspirin in heart attacks and following the placement of a coronary artery stent (dual antiplatelet therapy). [ 10 ]
View/Edit Human. View/Edit Mouse. P2Y12 is a chemoreceptor for adenosine diphosphate (ADP) [ 5 ][ 6 ] that belongs to the G i class of a group of G protein-coupled (GPCR) purinergic receptors. [ 7 ] This P2Y receptor family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various ...
Peripheral artery disease. Peripheral artery disease (PAD) is a vascular disorder that causes abnormal narrowing of arteries other than those that supply the heart or brain. [ 5 ][ 15 ] PAD can happen in any blood vessel, but it is more common in the legs than the arms. [ 16 ]
Prasugrel is a member of the thienopyridine class of ADP receptor inhibitors, like ticlopidine (trade name Ticlid) and clopidogrel (trade name Plavix). These agents reduce the aggregation ("clumping") of platelets by irreversibly binding to P2Y 12 receptors. Prasugrel inhibits platelet aggregation more rapidly, more consistently, and to a ...
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