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The EC 50 of androstanolone for activation of the AR is 0.13 nM, which is about 5-fold stronger than that of testosterone (EC 50 = 0.66 nM). [43] In bioassays, androstanolone has been found to be 2.5- to 10-fold more potent than testosterone. [41] Upon intramuscular injection in rats, androstanolone is about 1.5- to 2.5-fold the potency of ...
Testosterone undecanoate is a testosterone ester and a prodrug of testosterone in the body. [10] [9] [7] Because of this, it is considered to be a natural and bioidentical form of testosterone. [17] Testosterone undecanoate was introduced in China for use by injection and in the European Union for use by mouth in the 1970s.
Androsterone is a metabolite of testosterone and dihydrotestosterone (DHT). In addition, it can be converted back into DHT via 3α-hydroxysteroid dehydrogenase and 17β-hydroxysteroid dehydrogenase , bypassing conventional intermediates such as androstanedione and testosterone, and as such, can be considered to be a metabolic intermediate in ...
Testosterone esters were synthesized for the first time in 1936, and were found to have greatly improved potency relative to testosterone. [12] Among the esters synthesized, testosterone propionate was the most potent, and for this reason, was selected for further development, subsequently being marketed. [ 12 ]
Testosterone is a medication and naturally occurring steroid hormone. [9] It is used to treat male hypogonadism, gender dysphoria, and certain types of breast cancer. [9] [10] It may also be used to increase athletic ability in the form of doping. [9]
Androgen replacement therapy (ART), often referred to as testosterone replacement therapy (TRT), is a form of hormone therapy in which androgens, often testosterone, are supplemented or replaced. It typically involves the administration of testosterone through injections, skin creams, patches, gels, pills, or subcutaneous pellets.
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