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CSF albumin is a measurement used to determine the levels of albumin in cerebrospinal fluid. [1] A closely related test, CSF total protein is a measurement used to determine the levels of protein in cerebrospinal fluid. [2] [3] It combines the albumin, IgG, and other proteins. It can be useful in distinguishing among causes of Meningitis.
Cerebrospinal fluid (CSF) is a clear, colorless body fluid found within the tissue that surrounds the brain and spinal cord of all vertebrates. CSF is produced by specialized ependymal cells in the choroid plexus of the ventricles of the brain, and absorbed in the arachnoid granulations. In humans, there is about 125 mL of CSF at any one time ...
Proteins in the cerebrospinal fluid, normally albumin and globulin are present in the ratio of 8 to 1. Increases in protein levels are of diagnostic value in neurological diseases. The normal CSF is clear and transparent fluid. The Pandy's reaction makes it translucent or opaque.
For the analysis of cerebrospinal fluid, a sample is first collected via lumbar puncture (LP). Normally it is assumed that all the proteins that appear in the CSF, but are not present in the serum, are produced intrathecally (inside the central nervous system). Therefore, it is normal to subtract bands in serum from bands in CSF when ...
Hypoglycorrhachia (low CSF glucose levels) can be caused by CNS infections, inflammatory conditions, subarachnoid hemorrhage, hypoglycemia (low blood sugar), [3] impaired glucose transport (e.g. GLUT1 deficiency syndrome), increased CNS glycolytic activity and metastatic carcinoma.
Cerebral spinal fluid lymphocytic pleocytosis is generally the result of an immune response to neurovascular inflammation. Many cases point to a viral infection as the root cause of pleocytosis, in which the immune system produces antibodies against neuronal and vascular antigens .
Froin's syndrome – coexistence of xanthochromia, high protein level and marked coagulation of cerebrospinal fluid (CSF). It is caused by meningeal irritation (e.g. during spinal meningitis) and CSF flow blockage by tumour mass or abscess. [1]
Following is a list of reference ranges for cerebrospinal fluid: Ions and metals. Reference ranges for ions and ... Protein: 15 [1] [2] 40, [4] 45 [1] [2] mg/dL ~1% ...