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2. Vitamin C megadosage - Wikipedia

   en.wikipedia.org/wiki/Vitamin_C_megadosage

   There is a strong advocacy movement for very high doses of vitamin C, yet there is an absence of large-scale, formal trials in the 10 to 200+ grams per day range. The single repeatable side effect of oral megadose vitamin C is a mild laxative effect if the practitioner attempts to consume too much too quickly.

3. Intravenous ascorbic acid - Wikipedia

   en.wikipedia.org/wiki/Intravenous_ascorbic_acid

   [10] [11] A systematic review of trials in 2021 found that the claimed benefits of the protocol could not be confirmed. [12] People in sepsis may have micronutrient deficiencies, including low levels of vitamin C. [13] Reviews mention that an intake of 3.0 g/day via intravenous administration may needed to maintain normal plasma concentrations.

4. Vitamin C - Wikipedia

   en.wikipedia.org/wiki/Vitamin_C

   Vitamin C megadosage is a term describing the consumption or injection of vitamin C in doses comparable to or higher than the amounts produced by the livers of mammals which are able to synthesize vitamin C. An argument for this, although not the actual term, was described in 1970 in an article by Linus Pauling. Briefly, his position was that ...

5. Apixaban - Wikipedia

   en.wikipedia.org/wiki/Apixaban

   Apixaban is recommended by the National Institute for Health and Clinical Excellence for the prevention of stroke and systemic embolism in people with non-valvular atrial fibrillation and at least one of the following risk factors: prior stroke or transient ischemic attack, age 75 years or older, diabetes, or symptomatic heart failure.

6. Megavitamin therapy - Wikipedia

   en.wikipedia.org/wiki/Megavitamin_therapy

   Although Linus Pauling was known for highly respectable research in chemistry and biochemistry, he was also known for promoting the consumption of vitamin C in large doses. [25] Although he claimed and stood firm in his claim that consuming over 1,000 mg is helpful for one’s immune system when fighting a head cold, the results of empirical ...

7. Therapeutic index - Wikipedia

   en.wikipedia.org/wiki/Therapeutic_index

   The therapeutic index (TI; also referred to as therapeutic ratio) is a quantitative measurement of the relative safety of a drug with regard to risk of overdose.It is a comparison of the amount of a therapeutic agent that causes toxicity to the amount that causes the therapeutic effect. [1]

8. Dose (biochemistry) - Wikipedia

   en.wikipedia.org/wiki/Dose_(biochemistry)

   In single-dose scenarios, the patient's body weight and the drug's recommended dose per kilogram are used to determine a safe one-time dose. If multiple doses of treatment are needed in a day, the physician must take into account information regarding the total amount of the drug which is safe to use in one day, and how that should be broken up ...

9. Effective dose (pharmacology) - Wikipedia

   en.wikipedia.org/wiki/Effective_dose_(pharmacology)

   The median effective dose is the dose that produces a quantal effect (all or nothing) in 50% of the population that takes it (median referring to the 50% population base). [6] It is also sometimes abbreviated as the ED 50, meaning "effective dose for 50% of the population". The ED50 is commonly used as a measure of the reasonable expectancy of ...