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392 million (2015) [ 11] Type 2 diabetes ( T2D ), formerly known as adult-onset diabetes, is a form of diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin. [ 6] Common symptoms include increased thirst, frequent urination, fatigue and unexplained weight loss. [ 3]
Polygenic. Genetic cause and mechanism of type 2 diabetes is largely unknown. However, single nucleotide polymorphism (SNP) is one of many mechanisms that leads to increased risk for type 2 diabetes. To locate genes and loci that are responsible for the risk of type 2 diabetes, genome wide association studies (GWAS) was utilized to compare the ...
Endocrinology. Complications of diabetes are secondary diseases that are a result of elevated blood glucose levels that occur in diabetic patients. These complications can be divided into two types: acute and chronic. Acute complications are complications that develop rapidly and can be exemplified as diabetic ketoacidosis (DKA), hyperglycemic ...
Frequency. 4–25% of people with type 1 diabetes per year [ 1][ 5] Diabetic ketoacidosis ( DKA) is a potentially life-threatening complication of diabetes mellitus. [ 1] Signs and symptoms may include vomiting, abdominal pain, deep gasping breathing, increased urination, weakness, confusion and occasionally loss of consciousness. [ 1]
Diabetic nephropathy, also known as diabetic kidney disease, [ 5] is the chronic loss of kidney function occurring in those with diabetes mellitus. Diabetic nephropathy is the leading causes of chronic kidney disease (CKD) and end-stage renal disease (ESRD) globally. The triad of protein leaking into the urine (proteinuria or albuminuria ...
4.2 million (2019) [ 9] Diabetes mellitus, often known simply as diabetes, is a group of common endocrine diseases characterized by sustained high blood sugar levels. [ 10][ 11] Diabetes is due to either the pancreas not producing enough insulin, or the cells of the body becoming unresponsive to the hormone's effects. [ 12]
The insulin transduction pathway is a biochemical pathway by which insulin increases the uptake of glucose into fat and muscle cells and reduces the synthesis of glucose in the liver and hence is involved in maintaining glucose homeostasis. This pathway is also influenced by fed versus fasting states, stress levels, and a variety of other hormones.
Frequency. Relatively common [ 2] Hyperosmolar hyperglycemic state ( HHS ), also known as hyperosmolar non-ketotic state ( HONK ), is a complication of diabetes mellitus in which high blood sugar results in high osmolarity without significant ketoacidosis. [ 4][ 5] Symptoms include signs of dehydration, weakness, leg cramps, vision problems ...
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