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4,7-Dichloroquinoline was first reported in a patent filed by IG Farben in 1937. [2] However, its synthesis was not investigated in detail until chloroquine was developed as an antimalarial drug. [ 3 ] : 130–132 A route to the intermediate starting from 3-chloroaniline was developed by chemists at Winthrop Chemical Co .
Sodium bicarbonate and hypertonic saline may be used in cases of severe QRS complex widening. [11] Seizures may be treated with benzodiazepines . [ 25 ] Intravenous potassium chloride may be required, however this may result in high blood potassium later in the course of the disease. [ 25 ]
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n.o.s. = not otherwise specified meaning a collective entry to which substances, mixtures, solutions or articles may be assigned if a) they are not mentioned by name in 3.2 Dangerous Goods List AND b) they exhibit chemical, physical and/or dangerous properties corresponding to the Class, classification code, packing group and the name and description of the n.o.s. entry [2]
Different CAS Registry Numbers [1] are used for each form of a substance. For example, something simple like alanine will have one CAS# for the D form, another for L, another for "unspecified" and a fourth one for racemic. There would be another four CAS#s for the hydrochloride, four for the (1:1) sulfate, four for the (2:1)sulfate, etc.
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English: Synthesis of chloroquine from 4,7-dichloroquinoline and 1-Diethylamino-4-aminopentane. Date: 24 April 2020: Source: Own work: Author: Bert.Kilanowski: SVG ...