Search results
Results from the WOW.Com Content Network
Opioid-induced hyperalgesia (OIH) or opioid-induced abnormal pain sensitivity, also called paradoxical hyperalgesia, is an uncommon condition of generalized pain caused by the long-term use of high dosages of opioids [1] such as morphine, [2] oxycodone, [3] and methadone.
Sensory side effects include paresthesias, dysesthesias, numbness, altered proprioception, and loss of dexterity in fingers and toes. Motor and autonomic symptoms are less frequent but possible. Symptoms may start days after the patient receives their first dose of chemotherapy, are dose dependent, and tend to improve after completion of treatment.
Resultant plasma levels after subcutaneous (SC), intramuscular (IM), and IV injection are all comparable. After IM or SC injections, morphine plasma levels peak in approximately 20 min, and, after oral administration, levels peak in approximately 30 min. [81] Morphine is metabolised primarily in the liver and approximately 87% of a dose of ...
Morphine is effective in relieving cancer pain, [38] although oxycodone shows superior tolerability and analgesic effect, though cost may limit its value in certain healthcare systems. [39] Side effects of nausea and constipation are rarely severe enough to warrant stopping of treatment. [38]
Common side effects include dizziness, sleepiness, nausea, itchiness, and constipation. [7] Serious side effects may include abuse, low blood pressure, seizures, respiratory depression, and serotonin syndrome. [7] Rapidly decreasing the dose may result in opioid withdrawal. [7] Generally, use during pregnancy or breastfeeding is not recommended ...
Depending on the person, the cancer, the stage of cancer, the type of chemotherapy, and the dosage, intravenous chemotherapy may be given on either an inpatient or an outpatient basis. For continuous, frequent or prolonged intravenous chemotherapy administration, various systems may be surgically inserted into the vasculature to maintain access.
The systems of the body most affected by chemotherapy drugs include visual and semantic memory, attention and motor coordination and executive functioning. [9] [10] These effects can impair a chemotherapy patient's ability to understand and make decisions regarding treatment, perform in school or employment and can reduce quality of life. [10]
A chemotherapy regimen is a regimen for chemotherapy, defining the drugs to be used, their dosage, the frequency and duration of treatments, and other considerations. In modern oncology, many regimens combine several chemotherapy drugs in combination chemotherapy. The majority of drugs used in cancer chemotherapy are cytostatic, many via ...