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This gene encodes the MT 1 protein, one of two high-affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland.This receptor is a G protein-coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length.
Melatonin receptors are G protein-coupled receptors (GPCR) which bind melatonin. [1] Three types of melatonin receptors have been cloned.The MT 1 (or Mel 1A or MTNR1A) and MT 2 (or Mel 1B or MTNR1B) receptor subtypes are present in humans and other mammals, [2] while an additional melatonin receptor subtype MT 3 (or Mel 1C or MTNR1C) has been identified in amphibia and birds. [3]
The melatonin receptors are G protein-coupled receptors and are expressed in various tissues of the body. There are two subtypes of the receptor in humans, melatonin receptor 1 (MT 1) and melatonin receptor 2 (MT 2). [2] Melatonin and melatonin receptor agonists, on market or in clinical trials, all bind to and activate both receptor types. [1]
MT 1 protein, see Melatonin receptor 1A Topics referred to by the same term This disambiguation page lists articles associated with the same title formed as a letter–number combination.
n/a Ensembl ENSG00000205362 n/a UniProt P04731 n/a RefSeq (mRNA) NM_005946 n/a RefSeq (protein) NP_005937 n/a Location (UCSC) Chr 16: 56.64 – 56.64 Mb n/a PubMed search n/a Wikidata View/Edit Human Metallothionein-1A is a protein that in humans is encoded by the MT1A gene. References ^ a b c GRCh38: Ensembl release 89: ENSG00000205362 – Ensembl, May 2017 ^ "Human PubMed Reference ...
Interferon beta-1a, a drug; Meltwater pulse 1A, a period of rapid post-glacial sea level rise, 13,500–14,700 years ago; Melatonin receptor 1A, a human gene; Metallothionein 1A, a human gene; MH-1A, a nuclear power reactor and the first floating nuclear power station; Vasopressin receptor 1A, a major receptor type for vasopressin
Computer-mediated communication (CMC) is defined as any human communication that occurs through the use of two or more electronic devices. [1] While the term has traditionally referred to those communications that occur via computer-mediated formats (e.g., instant messaging, email, chat rooms, online forums, social network services), it has also been applied to other forms of text-based ...
This gene encodes the MT 2 protein, one of two high-affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain; however, this detection requires RT-PCR.