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If we compare the two different dosage forms having same active ingredients and compare the two drug bioavailability is called comparative bioavailability. [18] Although knowing the true extent of systemic absorption (referred to as absolute bioavailability) is clearly useful, in practice it is not determined as frequently as one may think.
Biological value (BV) is a measure of the proportion of absorbed protein from a food which becomes incorporated into the proteins of the organism's body. It captures how readily the digested protein can be used in protein synthesis in the cells of the organism.
This second process is where the absorbed food reaches the cells via the liver. Most foods are composed of largely indigestible components depending on the enzymes and effectiveness of an animal's digestive tract. The most well-known of these indigestible compounds is cellulose; the basic chemical polymer in the
Drug metabolism is the metabolic breakdown of drugs by living organisms, usually through specialized enzymatic systems. More generally, xenobiotic metabolism (from the Greek xenos "stranger" and biotic "related to living beings") is the set of metabolic pathways that modify the chemical structure of xenobiotics, which are compounds foreign to an organism's normal biochemistry, such as any drug ...
Cell membranes may act as barriers to some drugs. They are essentially lipid bilayers which form semipermeable membranes. Pure lipid bilayers are generally permeable only to small, uncharged solutes. Hence, whether or not a molecule is ionized will affect its absorption, since ionic molecules are charged. Solubility favors charged species, and ...
Factors that affect distribution [ edit ] There are many factors that affect a drug's distribution throughout an organism, but Pascuzzo [ 1 ] considers that the most important ones are the following: an organism's physical volume, the removal rate and the degree to which a drug binds with plasma proteins and / or tissues.
These factors consist of certain cell surface proteins and transcription factors that induce the uptake of DNA. [1] Natural competence is the ability of a cell to bind to and transport extracellular DNA through the membrane and recombine foreign genes into its own DNA through a process called transformation. [2]
Cell membranes present a greater barrier to the movement of ionized molecules than non-ionized liposoluble substances. This is particularly important for substances that are weakly amphoteric . The stomach's acidic pH and the subsequent alkalization in the intestine modifies the degree of ionization of acids and weak bases depending on a ...