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  2. What Should I Do If Viagra Is Not Working for Me? - AOL

    www.aol.com/viagra-not-working-185700342.html

    Men with ED were given the 50mg sildenafil dose to be taken as needed before sex. After two weeks, those with no issues with the drug were moved up to the 100mg dose.

  3. Sildenafil - Wikipedia

    en.wikipedia.org/wiki/Sildenafil

    Sildenafil is a potent and selective inhibitor of cGMP-specific phosphodiesterase type 5 ... low-dose form of sildenafil have been ... of Viagra, on the day the ...

  4. Is Sildenafil Safe for This Common Male Problem? - AOL

    www.aol.com/sildenafil-safe-common-male-problem...

    Sildenafil is most commonly prescribed to be taken one time per day in doses between 25 and 100 mg for ED. Your healthcare provider will determine the best dosage for you based on a number of factors.

  5. How to Take Viagra for Best Results - AOL

    www.aol.com/viagra-best-results-105700318.html

    When to Take Viagra: 30-60 Minutes Before Intimacy, Not Earlier. If you’re planning to have intimacy, it’s best to take your recommended dose of Viagra ahead of time.

  6. cGMP-specific phosphodiesterase type 5 - Wikipedia

    en.wikipedia.org/wiki/CGMP-specific_phosphodi...

    Sildenafil (marketed as Viagra) was the first PDE5 inhibitor on the market. Originally created as a treatment for high blood pressure in 1989, it was found to have a secondary use as an effective PDE5 inhibitor, enabling men who use it to gain stronger erections after arousal. The FDA approved Viagra on March 27, 1998. [20]

  7. Things You Probably Don't Know About Viagra (Like What ... - AOL

    www.aol.com/things-probably-dont-know-viagra...

    This is thanks to an enzyme called phosphodiesterase type 5 (PDE5). Viagra inhibits PDE5 and acts as a vasodilator (something that dilates blood vessels and increases blood flow). ... one dose is ...

  8. PDE5 inhibitor - Wikipedia

    en.wikipedia.org/wiki/PDE5_inhibitor

    Chemical structure of sildenafil (Viagra), the prototypical PDE5 inhibitor. A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying various tissues.

  9. What Does Viagra Actually Do to Your "Intimate" Experience? - AOL

    www.aol.com/does-viagra-actually-intimate...

    For example, a small study of 20 people that looked into Viagra’s effect on refractory time found that a standard 100mg dose of sildenafil citrate reduced the average male post-intimacy recovery ...

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