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Nicotinamide N-methyltransferase (NNMT) is an enzyme that in humans is encoded by the NNMT gene. [5] NNMT catalyzes the methylation of nicotinamide and similar compounds using the methyl donor S-adenosyl methionine (SAM-e) to produce S-adenosyl-L-homocysteine (SAH) and 1-methylnicotinamide. [6]
In enzymology, a nicotinamide N-methyltransferase (NNMT) (EC 2.1.1.1) is an enzyme that catalyzes the chemical reaction S-adenosyl-L-methionine + nicotinamide ⇌ {\displaystyle \rightleftharpoons } S-adenosyl-L-homocysteine + 1-methylnicotinamide.
NNMT (nicotinamide N-methyltransferase) is an enzyme that in humans is encoded by the NNMT gene. [6] NNMT catalyzes the methylation of nicotinamide and similar compounds using the methyl donor S-adenosyl methionine (SAM-e) to produce S-adenosyl-L-homocysteine (SAH) and 1-methylnicotinamide. [7] NNMT is highly expressed in the human liver. [7]
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Nicotinamide is in the vitamin B family of medications, specifically the vitamin B 3 complex. [10] [11] It is an amide of nicotinic acid. [7] Foods that contain nicotinamide include yeast, meat, milk, and green vegetables. [12] Nicotinamide was discovered between 1935 and 1937. [13] [14] It is on the World Health Organization's List of ...
NNMT: nicotinamide N-methyltransferase; NRGN: neurogranin; OR2AG2: encoding protein Olfactory receptor family 2 subfamily ag member 2; P53AIP1: p53-regulated apoptosis-inducing protein 1; PANO1: encoding protein PANO1; PAX6: paired box 6; PCNX3 encoding protein Pecanex homolog 3; PGA3 encoding protein Pepsinogen 3, group I (pepsinogen A)